Recombinant Human ASRGL1 protein (His tag N-Terminus)
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Recombinant Human ASRGL1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 308 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
ALP, CRASH, ASRGL1, Isoaspartyl peptidase/L-asparaginase, Asparaginase-like protein 1, Beta-aspartyl-peptidase, Isoaspartyl dipeptidase, L-asparagine amidohydrolase
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ASRGL1 protein (AB187483)
15% SDS-PAGE analysis of ab187483 (3 μg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ASRGL1 contributes to the metabolism of amino acids and is involved in cellular processes that require protein catabolism. The protein is not typically part of a larger complex functioning independently to facilitate chemical reactions important for maintaining amino acid balance. Through its enzymatic activities ASRGL1 supports cellular function and protein turnover highlighting its importance in basic cellular metabolism.
Pathways
The ASRGL1 protein participates in the glutamine and glutamate metabolism pathway. It also plays a role in the urea cycle keeping a balance between nitrogen and amino acid levels. In these pathways ASRGL1 interacts with proteins like glutaminase and carbamoyl phosphate synthetase 1 which have roles in nitrogen metabolism and energy production. These interactions emphasize the protein's integration in fundamental metabolic processes.
Specifications
Form
Liquid
Additional notes
ab187483 was purified using conventional chromatography.
General info
Function
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
Sequence similarities
Belongs to the Ntn-hydrolase family.
Post-translational modifications
Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.
Target data
Product promise
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