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AB198150

Recombinant human ATAD2B protein

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Recombinant human ATAD2B protein is a Human Fragment protein, in the 953 to 1080 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, FuncS.

View Alternative Names

KIAA1240, ATAD2B, ATPase family AAA domain-containing protein 2B

2 Images
Functional Studies - Recombinant human ATAD2B protein (AB198150)
  • FuncS

Supplier Data

Functional Studies - Recombinant human ATAD2B protein (AB198150)

Specific activity of ab198150.

SDS-PAGE - Recombinant human ATAD2B protein (AB198150)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human ATAD2B protein (AB198150)

4-20% SDS-PAGE analysis of ab198150 (2μg) with Coomassie staining.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

GST tag N-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Active

Accession

Q9ULI0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.48% Tris, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSEDQEENTLRELRLFLRDVTKRLATDKRFNIFSKPVDIEEVSDYLEVIKEPMDLSTVITKIDKHNYLTAKDFLKDIDLICSNALEYNPDKDPGDKIIRHRACTLKDTAHAIIAAELDPEFNKLCEEIKE","proteinLength":"Fragment","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":1080,"aminoAcidStart":953,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9ULI0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATAD2B also known as ATPase family AAA domain-containing protein 2B is an ATPase of about 150 kDa known to have an important role in chromatin remodeling. It binds to DNA and catalyzes ATP-dependent chromatin assembly and disassembly. ATAD2B shows high expression in the brain and reproductive tissues. In cellular contexts ATAD2B participates in energy transfer and conversion contributing to cellular processes that require mechanical energy.
Biological function summary

ATAD2B influences gene expression by altering chromatin structure. It participates in chromatin dynamics potentially forming part of multiprotein complexes that impact transcriptional regulation. Its activity impacts the accessibility of transcription factors to DNA influencing numerous cellular functions. Despite not being a direct part of well-known complexes like SWI/SNF its role suggests a contributory function to chromatin-related biological processes.

Pathways

ATAD2B plays a functional role in the PI3K/AKT signaling pathway interacting with proteins like AKT1. It also contributes to the regulation of the WNT signaling pathway which involves interactions with important signaling proteins such as beta-catenin. These pathways control cell growth and differentiation linking ATAD2B to critical cellular activities.

Researchers associate ATAD2B with neurological disorders especially those affecting cognitive function due to its significant brain expression. It may also relate to certain cancers where chromatin remodeling is essential. Changes in ATAD2B interactions possibly with proteins like AKT1 or beta-catenin might influence disease progression and severity underlining its potential as a biomarker or therapeutic target.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the AAA ATPase family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

See full target information ATAD2B
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