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AB152203

Recombinant Human ATP1A3 protein (GST tag N-Terminus)

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Recombinant Human ATP1A3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 1013 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

Sodium/potassium-transporting ATPase subunit alpha-3, Na(+)/K(+) ATPase alpha-3 subunit, Na(+)/K(+) ATPase alpha(III) subunit, Sodium pump subunit alpha-3, ATP1A3

1 Images
SDS-PAGE - Recombinant Human ATP1A3 protein (GST tag N-Terminus) (AB152203)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ATP1A3 protein (GST tag N-Terminus) (AB152203)

12.5% SDS-PAGE analysis of ab152203 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

P13637

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB182571

Anti-ATP1A3 antibody [EPR14138]

RabMAb|Recombinant|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-ATP1A3 antibody [EPR14138] (AB182571)

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Proteins & Peptides

AB140806

Recombinant Human Parkin protein

SDS-PAGE - Recombinant Human Parkin protein (AB140806)

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Proteins & Peptides

AB159891

Recombinant Human PXDN/VPO1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human PXDN/VPO1 protein (GST tag N-Terminus) (AB159891)

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Proteins & Peptides

AB316437

Recombinant Mouse NT-ProANP Protein Standard

Sandwich ELISA - Recombinant Mouse NT-ProANP Protein Standard (AB316437)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as alpha 3 Sodium Potassium ATPase.
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Sequence info

[{"sequence":"MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY","proteinLength":"Full Length","predictedMolecularWeight":"138.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":1013,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P13637","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATP1A3 also known as the alpha3 subunit of the sodium-potassium ATPase is an ion pump that functions to maintain the electrochemical gradients of sodium and potassium ions across the plasma membrane. It is a protein with a molecular mass of approximately 110 kDa. ATP1A3 expression is found mainly in neurons of the central nervous system. By actively transporting three sodium ions out of the cell and two potassium ions into the cell ATP1A3 helps sustain the resting potential essential for neuronal excitability and signaling.
Biological function summary

The sodium-potassium ATPase where ATP1A3 serves acts as a vital component in maintaining ion homeostasis. This protein resides in cell membranes and forms a part of the larger complex required for normal neuron function. Its activity also influences other cell functions like cell volume regulation and signal transduction processes. The alpha3 subunit specifically exhibits specialized roles in neuronal tissues where rapid Na+ and K+ exchange is necessary contributing significantly to nerve impulse transmission.

Pathways

The function of ATP1A3 is integral in the maintenance of the membrane potential which is an important part of many physiological pathways including the action potential propagation in neurons. Another pathway where its activity is significant involves synaptic vesicle cycling which depends on ATP1A3 to maintain ionic conditions for synaptic transmission. Proteins such as the beta subunit of the sodium-potassium ATPase ATP1B1 closely associate with ATP1A3 and modulate its activity and stability.

Mutations in ATP1A3 have associations with neurological conditions such as Alternating Hemiplegia of Childhood (AHC) and Rapid-Onset Dystonia-Parkinsonism (RDP). These disorders are characterized by sudden severe disruptions in motor function that relate to impaired ion gradients caused by dysfunctional ATP1A3. In AHC the disrupted interaction of ATP1A3 with other ion pumps like ATP1A2 exacerbates neurological function deficits.
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Specifications

Form

Liquid

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General info

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

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Product protocols

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Target data

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
See full target information ATP1A3
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