Recombinant Human ATP1B2 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATP1B2 also known as Sodium/potassium-transporting ATPase subunit beta-2 is a protein that functions mechanically as part of the Na+/K+ pump essential for maintaining the electrochemical gradients of sodium and potassium ions across the plasma membrane. This protein is approximately 40 kDa in mass. It is particularly expressed in nervous tissues such as brain and spinal cord but can be found in many other tissues as well. ATP1B2 plays a significant role in ion transport and regulation of cell volume as well as maintaining resting potential.

Biological function summary

ATP1B2 participates in the assembly of the Na+/K+ ATPase enzyme complex a complex vital for proper ion exchange and cellular homeostasis. It stabilizes the enzyme's alpha subunit and ensures correct localization within the cell membrane. This complex is essential for cellular processes like neuronal signaling and muscle contraction as it helps in maintaining the appropriate ion balance within the cells.

Pathways

ATP1B2 is involved in the ion transport pathway important for maintaining cellular ion homeostasis. It is part of pathways such as the sodium reabsorption in kidneys and nerve transmission. In these pathways ATP1B2 works closely with proteins like ATP1A1 the alpha subunit of the Na+/K+ ATPase helping to facilitate the transport of sodium out of and potassium into the cells which is critical for many physiological processes.

ATP1B2 has been linked to conditions such as epilepsy and certain types of congenital heart disease. In epilepsy dysfunctional ion transport due to anomalies in ATP1B2 can lead to abnormal neuronal firing. Another related protein ATP1A2 also plays a part in neurological disorders through similar ion transport mechanisms. In congenital heart disease disruptions in the Na+/K+ pump imaging can affect heart function demonstrating ATP1B2's role in maintaining cardiovascular health.