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AB116917

Recombinant Human ATP6V1C1 protein (GST tag N-Terminus)

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Recombinant Human ATP6V1C1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 1 to 110 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

ATP6C, ATP6D, VATC, ATP6V1C1, V-type proton ATPase subunit C 1, V-ATPase subunit C 1, Vacuolar proton pump subunit C 1

1 Images
SDS-PAGE - Recombinant Human ATP6V1C1 protein (GST tag N-Terminus) (AB116917)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ATP6V1C1 protein (GST tag N-Terminus) (AB116917)

12.5% SDS-PAGE stained with Coomassie Blue showing ab116917 at approximately 37.73 kDa.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

P21283

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB272594

Anti-ATP6V1C1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1C1 antibody (AB272594)

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  • 0
Reagents, Controls & Accessories

AB7481

Normal Goat Serum

Immunohistochemistry (Frozen sections) - Normal Goat Serum (AB7481)

  • 5
  • 3
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB195045

Anti-PAX6 antibody [EPR15858]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAX6 antibody [EPR15858] (AB195045)

  • 5
  • 9
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>(Recombinant protein).</p>" } } }
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Sequence info

[{"sequence":"MTEFWLISAPGEKTCQQTWEKLHAATSKNNNLAVTSKFNIPDLKVGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLANGVDLVTYITRFQWDMA","proteinLength":"Fragment","predictedMolecularWeight":"37.73 kDa","actualMolecularWeight":null,"aminoAcidEnd":110,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P21283","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATP6V1C1 also known as ATPase H+ transporting V1 subunit C1 is a component of the V1 sector of the V-ATPase complex with a mass around 45 kDa. It is a part of the proton pump which plays an important role in acidifying intracellular compartments. ATP6V1C1 is expressed in various tissues with high levels seen in kidney liver and lungs. Its function as a subunit involves assembly stability and regulation of the ATPase complex which is essential for translocating protons across membranes.
Biological function summary

ATP6V1C1 functions within the V-ATPase complex that consists of V1 and V0 domains. This complex actively transports hydrogen ions (H+) across organelle membranes and plasma membranes which is important for processes such as protein degradation receptor-mediated endocytosis and neurotransmitter release. The activity of ATP6V1C1 supports cellular homeostasis by maintaining the acidic environment required for these processes.

Pathways

ATP6V1C1 plays a role in important pathways such as lysosomal acidification and bone resorption. It closely interacts with other V-ATPase subunits such as ATP6V0D1 in these pathways. The V-ATPase activity in lysosomal acidification facilitates the function of lysosomal enzymes while in bone resorption it helps osteoclasts to dissolve bone minerals highlighting its significance in both metabolic and skeletal systems.

ATP6V1C1 has a connection to osteopetrosis and renal tubular acidosis. Mutations or dysfunction in ATP6V1C1 may lead to impaired V-ATPase function influencing disease progression. Osteopetrosis is connected through its effect on osteoclast function while ATP6V1C1's role in acidifying urine implicates it in renal tubular acidosis. Its interactions with other proteins like ATP6V0A4 further elaborate its involvement in these diseases impacting treatment and research directions.
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Specifications

Form

Liquid

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General info

Function

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed : 33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).

Sequence similarities

Belongs to the V-ATPase C subunit family.

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Product protocols

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Target data

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed : 33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity).
See full target information ATP6V1C1
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