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AB289750

Recombinant Human ATRAP protein

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Recombinant Human ATRAP protein is a Human Full Length protein, in the 1 to 159 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

View Alternative Names

ATRAP, AGTRAP, Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein

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SDS-PAGE - Recombinant Human ATRAP protein (AB289750)
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Supplier Data

SDS-PAGE - Recombinant Human ATRAP protein (AB289750)

SDS-PAGE analysis of ab289750

Key facts

Purity

>85% SDS-PAGE

Expression system

Cell free

Tags

10x His tag N-Terminus SUMO tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6RW13

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% dodecyl 2-(trimethylazaniumyl)ethyl phosphate

storage-buffer

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Complementary Products

Primary Antibodies

AB85175

Anti-ATRAP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATRAP antibody (AB85175)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY","proteinLength":"Full Length","predictedMolecularWeight":"37.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":159,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q6RW13","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ATRAP also known as Angiotensin II Type 1 Receptor-Associated Protein functions mainly by interacting directly with the Angiotensin II Type 1 Receptor (AT1R) to modulate its signaling. It weighs approximately 17 kDa and is expressed widely in tissues particularly within the kidney cardiovascular system and adipose tissues. ATRAP influences membrane localization and activity of the AT1R impacting various cellular responses.
Biological function summary

ATRAP limits excessive angiotensin II signaling by promoting internalization and degradation of the AT1R. Through this process it helps reduce cellular proliferation and inflammation often mediated by the receptor. ATRAP operates as a negative regulator maintaining balance in the renin-angiotensin system. It can function as part of multiprotein complexes involving AT1R and other signaling intermediates.

Pathways

ATRAP plays a role within the renin-angiotensin-aldosterone system (RAAS) which is critical for blood pressure regulation and fluid balance. It interacts with proteins like AT1R to modulate effects of angiotensin II. The action of ATRAP affects pathways connected to oxidative stress and inflammation indicating its broader influence in cardiovascular modulation.

ATRAP has involvement in hypertension and cardiovascular disease. Its ability to modulate AT1R signaling links it to conditions characterized by heightened angiotensin II activity. Research connects ATRAP with cardiac remodeling highlighting it alongside proteins like angiotensin-converting enzyme (ACE) in disease progression. Increasing ATRAP levels may provide therapeutic benefits in managing these conditions.
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Specifications

Form

Lyophilized

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General info

Function

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

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Product protocols

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Target data

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
See full target information AGTRAP
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Product promise

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