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AB276604

Recombinant Human B3GALTL protein (His tag)

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Recombinant Human B3GALTL protein (His tag) is a Human Fragment protein, in the 29 to 494 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

B3GALTL, B3GTL, B3GLCT, Beta3Glc-T, Beta 3-glucosyltransferase, Beta-3-glycosyltransferase-like

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SDS-PAGE - Recombinant Human B3GALTL protein (His tag) (AB276604)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human B3GALTL protein (His tag) (AB276604)

SDS-PAGE analysis of ab276604

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6Y288

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"SEDTKKEVKQSQDLEKSGISRKNDIDLKGIVFVIQSQSNSFHAKRAEQLKKSILKQAADLTQELPSVLLLHQLAKQEGAWTILPLLPHFSVTYSRNSSWIFFCEEETRIQIPKLLETLRRYDPSKEWFLGKALHDEEATIIHHYAFSENPTVFKYPDFAAGWALSIPLVNKLTKRLKSESLKSDFTIDLKHEIALYIWDKGGGPPLTPVPEFCTNDVDFYCATTFHSFLPLCRKPVKKKDIFVAVKTCKKFHGDRIPIVKQTWESQASLIEYYSDYTENSIPTVDLGIPNTDRGHCGKTFAILERFLNRSQDKTAWLVIVDDDTLISISRLQHLLSCYDSGEPVFLGERYGYGLGTGGYSYITGGGGMVFSREAVRRLLASKCRCYSNDAPDDMVLGMCFSGLGIPVTHSPLFHQARPVDYPKDYLSHQVPISFHKHWNIDPVKVYFTWLAPSDEDKARQETQKGF","proteinLength":"Fragment","predictedMolecularWeight":"55.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":494,"aminoAcidStart":29,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6Y288","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The B3GALTL protein also known as beta-13-galactosyltransferase-like protein is an enzyme with an approximate mass of 65 kDa. It adds galactose to specific glycoproteins and plays a role in the O-fucosylation of thrombospondin type 1 repeats. B3GALTL is expressed in various tissues including the placenta and brain. It participates in glycosylation processes that are essential for protein function and stability within the cell.
Biological function summary

The B3GALTL protein participates in glycosylation mechanisms necessary for the functionality of numerous proteins. This enzyme acts independently rather than as part of a complex to catalyze glycosidic bond formation which is integral to modifying proteins like Notch and Thrombospondin. It ensures that proteins acquire correct structural conformations optimizing their interactions and functions within the cellular environment.

Pathways

B3GALTL engages in the Notch signaling pathway and the biosynthesis of glycan structures. This protein's glycosylation activity directly impacts these pathways influencing cellular communication and signaling. It interacts with proteins like fucosyltransferases within these processes further highlighting its role in modifying the activity and stability of signaling pathways vital for cellular functions.

B3GALTL mutations associate with Peters Plus syndrome a genetic condition characterized by developmental delays and eye abnormalities. Another disorder linked to this protein is Atrial Septal Defect associated with thrombosis abnormalities. In these contexts B3GALTL interacts with proteins involved in vascularization and ocular development emphasizing its importance in maintaining cellular and tissue homeostasis.
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Specifications

Form

Lyophilized

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General info

Function

Beta-1,3-glucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological processes. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. It starts with POFUT2, which attaches fucose via an O-glycosidic bond to a conserved serine or threonine residue. B3GLCT extends this modification by transferring a glucose molecule from UDP-glucose to the fucose.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

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Product protocols

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Target data

Beta-1,3-glucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological processes. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. It starts with POFUT2, which attaches fucose via an O-glycosidic bond to a conserved serine or threonine residue. B3GLCT extends this modification by transferring a glucose molecule from UDP-glucose to the fucose.
See full target information B3GLCT
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