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AB276391

Recombinant Human B3GNT1 protein (Fc Chimera)

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Recombinant Human B3GNT1 protein (Fc Chimera) is a Human Fragment protein, in the 29 to 397 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

B3GALT7, B3GNT1, B3GNT2, Beta-3-Gx-T7, BGnT-1, Beta3Gn-T1, Beta3Gal-T7, Beta3GalT7, b3Gal-T7, BGnT-2, Beta3Gn-T2

1 Images
SDS-PAGE - Recombinant Human B3GNT1 protein (Fc Chimera) (AB276391)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human B3GNT1 protein (Fc Chimera) (AB276391)

SDS-PAGE analysis of ab276391

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NY97

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"KSSSQEKNGKGEVIIPKEKFWKISTPPEAYWNREQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFLLYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVFLLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEFVFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLYPPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEEKNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC","proteinLength":"Fragment","predictedMolecularWeight":"71.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":397,"aminoAcidStart":29,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9NY97","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B3GNT1 also known as UDP-GlcNAc:betaGal beta-13-N-acetylglucosaminyltransferase 1 is an enzyme that participates in glycosylation processes by transferring N-acetylglucosamine from UDP-GlcNAc to polylactosamine chains playing an important role in the synthesis of poly-N-acetyllactosamine. This protein has a mass of approximately 43 kDa and predominantly expresses in tissues that produce substantial amounts of glycosylated molecules such as the brain and the gastrointestinal tract.
Biological function summary

B3GNT1 contributes to the synthesis of glycan structures that are important for cell-cell interactions. It functions as an independent enzyme rather than as part of a larger enzymatic complex. The activity of B3GNT1 impacts the production of complex-type N- and O-glycans which support cellular adhesion signaling and immune recognition. Such functions make B3GNT1 significant in various physiological processes particularly in the development and maintenance of tissues.

Pathways

B3GNT1 is integral to the glycosaminoglycan biosynthesis and glycoprotein metabolic pathways. It interacts with other enzymes involved in these pathways such as beta-14-galactosyltransferase to construct poly-N-acetyllactosamine structures. The connectivity between B3GNT1 and other glycosyltransferases ensures proper assembly and function of glycan-containing molecules necessary for diverse biological activities.

Aberrant expression or malfunction of B3GNT1 links to conditions like congenital disorders of glycosylation and certain cancers. Abnormal glycosylation patterns sometimes involving related proteins such as FUT8 which is another glycosyltransferase can lead to defective cellular signaling and contribute to these pathologies. Understanding these connections helps in exploring therapeutic targets and diagnostic markers for glycosylation-related diseases.
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Specifications

Form

Lyophilized

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General info

Function

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed : 9892646). Probably constitutes the main polylactosamine synthase.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

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Product protocols

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Target data

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed : 9892646). Probably constitutes the main polylactosamine synthase.
See full target information B3GNT2
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