JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB191960

Recombinant Human B4GALT3 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human B4GALT3 protein is a Human Fragment protein, in the 32 to 393 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

Beta4Gal-T3, b4Gal-T3, N-acetyllactosamine synthase, Nal synthase, B4GALT3

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

O60512

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 10% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.32% Tris HCl, 0.02% Magnesium chloride

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"RSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGSHVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":393,"aminoAcidStart":32,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O60512","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B4GALT3 also known as Beta-14-galactosyltransferase 3 is an enzyme that plays an important role in transferring galactose from UDP-galactose to N-acetylglucosamine on polypeptides forming N-linked oligosaccharides. The enzyme is about 43 kDa in mass. It is mainly expressed in the Golgi apparatus of cells influencing the biosynthesis of glycoconjugates. B4GALT3 activity is evident across various tissues showing a broad expression pattern.
Biological function summary

B4GALT3 contributes significantly to the biosynthesis and modification of glycoproteins and glycolipids. It is a part of the glycosyltransferase family which functions in forming glycosidic bonds. This enzyme does not work alone; it often associates with other enzymes within the Golgi complex supporting diverse cellular processes like cell adhesion and receptor-ligand interactions by creating complex glycans.

Pathways

B4GALT3 is involved in the N-glycan biosynthesis and glycosaminoglycan biosynthesis pathways. In these pathways B4GALT3 interacts with proteins such as GlcNAcT glycosyltransferases aiding in the structural diversification of glycoconjugates. These pathways are essential for proper cell surface receptor function and signaling linking B4GALT3 to processes necessary for normal cell communication and structural integrity.

Alterations in B4GALT3 activity have associations with congenital disorders of glycosylation and certain cancers. Changes in glycosylation patterns by B4GALT3 can influence tumor progression and metastasis by impacting cellular recognition and adhesion. The enzyme also interacts with proteins like α3β1 integrin in cancer influencing cell movement and survival. Understanding these links could help target B4GALT3 in therapeutic strategies for these conditions.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

Sequence similarities

Belongs to the glycosyltransferase 7 family.

style
left-column

Product protocols

style
left-column

Target data

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
See full target information Beta-1,4-galactosyltransferase 3
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB74825

Anti-B4GALT3 antibody

Western blot - Anti-B4GALT3 antibody (AB74825)

  • 0
  • 0
Proteins & Peptides

AB276581

Recombinant Human DEGA protein (His tag)

SDS-PAGE - Recombinant Human DEGA protein (His tag) (AB276581)

  • 0
  • 0
Primary Antibodies

AB129742

Anti-ATP5G3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP5G3 antibody (AB129742)

  • 0
  • 0
Proteins & Peptides

AB276606

Recombinant Human PLAC9 protein (Fc Chimera)

SDS-PAGE - Recombinant Human PLAC9 protein (Fc Chimera) (AB276606)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com