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AB160437

Recombinant Human B4GALT5 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human B4GALT5 protein (GST tag N-Terminus) is a Human Fragment protein, in the 48 to 151 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Beta4Gal-T5, b4Gal-T5, Lactosylceramide synthase, LacCer synthase, B4GALT5

1 Images
SDS-PAGE - Recombinant Human B4GALT5 protein (GST tag N-Terminus) (AB160437)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human B4GALT5 protein (GST tag N-Terminus) (AB160437)

ab160437 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O43286

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB110398

Anti-B4GALT5 antibody

Western blot - Anti-B4GALT5 antibody (AB110398)

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Proteins & Peptides

AB159808

Recombinant Human ZAN protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Proteins & Peptides

AB162570

Recombinant Human VCX-A protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VCX-A protein (AB162570)

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Proteins & Peptides

AB163077

Recombinant Human VNN3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human VNN3 protein (AB163077)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"AQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGG","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":151,"aminoAcidStart":48,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43286","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

B4GALT5 also known as beta-14-galactosyltransferase 5 is an enzyme critical for glycosylation processes. This enzyme has a molecular weight of approximately 43 kDa. It adds galactose to specific carbohydrate structures and plays a role in forming lactose and other glycan structures. This enzyme is part of the larger beta-14-galactosyltransferase family and is found in the Golgi apparatus. It is expressed in various tissues with significant activity in the liver and kidney and to a certain extent in the brain.
Biological function summary

B4GALT5 is involved in the synthesis of complex glycoconjugates and lactose. It contributes to the N-linked and O-linked glycosylation of proteins which are essential for protein folding stability and cell signaling. B4GALT5 forms part of the enzyme complex responsible for elongating glycan chains cooperating with other glycosyltransferases. Through its enzymatic activity it affects cell-cell interactions host-pathogen recognition and immune responses.

Pathways

B4GALT5 is an important component of the glycan biosynthesis and metabolism pathways. Its action affects the glycoprotein quality control and folding pathways. In these processes it works alongside other glycosyltransferases such as B4GALT1 ensuring proper glycoconjugate formation and modification. These pathways influence developmental processes immune system functions and normal cellular operations.

B4GALT5 has links to congenital disorders of glycosylation and cancer. Abnormal glycosylation can alter cell adhesion and migration contributing to tumorigenesis and metastasis. The enzyme shows altered expression levels in certain cancers suggesting its role as a potential biomarker. B4GALT5 has associations with other proteins like E-cadherin where changes in glycosylation patterns can influence cancer progression and immune evasion.
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Specifications

Form

Liquid

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General info

Function

Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed : 24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).

Sequence similarities

Belongs to the glycosyltransferase 7 family.

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Product protocols

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Target data

Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed : 24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity).
See full target information B4GALT5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Analytica chimica acta 1205:339739 PubMed35414399

2022

Peptide-based simple detection of SARS-CoV-2 with electrochemical readout.

Applications

Unspecified application

Species

Unspecified reactive species

Dayana Soto,Jahir Orozco
View all publications
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