Recombinant Human B7-H6 protein (Fc Chimera) is a Human Fragment protein, in the 25 to 262 aa range, expressed in HEK 293, with >98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE.
D L K V E M M A G G T Q I T P L N D N V T I F C N I F Y S Q P L N I T S M G I T W F W K S L T F D K E V K V F E F F G D H Q E A F R P G A I V S P W R L K S G D A S L R L P G I Q L E E A G E Y R C E V V V T P L K A Q G T V Q L E V V A S P A S R L L L D Q V G M K E N E D K Y M C E S S G F Y P E A I N I T W E K Q T Q K F P H P I E I S E D V I T G P T I K N M D G T F N V T S C L K L N S S Q E D P G T V Y Q C V V R H A S L H T P L R S N F T L T A A R H S L S E T E K T D N F S
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Triggers NCR3-dependent natural killer cell activation.
B7H6, NCR3LG1, Natural cytotoxicity triggering receptor 3 ligand 1, B7 homolog 6, B7-H6
Recombinant Human B7-H6 protein (Fc Chimera) is a Human Fragment protein, in the 25 to 262 aa range, expressed in HEK 293, with >98% purity, < 5 EU/mg endotoxin level and suitable for SDS-PAGE.
Constituents: 100% PBS
Triggers NCR3-dependent natural killer cell activation.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
B7-H6 also called NCR3LG1 is a cell surface protein functioning as a ligand for the NKp30 receptor. The protein weighs approximately 55 kDa and is mainly expressed on tumor cells and certain activated immune cells. Scientists often use tools like B7-H6 flow assays to study its expression patterns in various cell types. In the immune landscape B7-H6 interacts with NKp30 to stimulate natural killer (NK) cell activation and mediate immune responses.
B7-H6 acts as an important component in natural killer cell-mediated cytotoxicity. The protein is not part of a larger complex but operates independently to engage NK cell activity. It serves as a signal for NK cells to identify and destroy tumor cells. Additionally B7-H6 expression on tumor cells often correlates with immune cell recognition thereby playing an important role in tumor immunity.
B7-H6 participates in the immune response pathways connected to natural killer cell activation. Specifically it interacts with proteins like NKp30 as part of the natural cytotoxicity triggering receptor signaling process. These interactions facilitate the destruction of target cells enhancing the body's innate immune response by activating downstream pathways vital to immune defense.
B7-H6 has associations with cancer and infectious diseases. In several cancer types including mesothelioma the protein's elevated expression can serve as an indicator of tumorigenesis. B7-H6 alongside its partner NKp30 potentially plays a role in immune escape mechanisms employed by tumors. Understanding this interaction offers insights into novel therapeutic strategies for tackling such conditions.
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