Recombinant Human BBS1 protein is a Human Full Length protein, in the 1 to 463 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M S P G P Q L W H L L Q A L V S M C I R I S D P T S S S A Y P N C L Q I L W N K T F G T R P K R E T A E E P L S I Q S L R F L Q L E L S E M E A F V N Q H K S N S I K R Q T V I T T M T T L K K N L A D E D A V S C L V L G T E N K E L L V L D P E A F T I L A K M S L P S V P V F L E V S G Q F D V E F R L A A A C R N G N I Y I L R R D S K H P K Y C I E L S A Q P V G L I R V H K V L V V G S T Q D S L H G F T H K G K K L W T V Q M P A A I L T M N L L E Q H S R G L Q A V M A G L A N G E V R I Y R D K A L L N V I H T P D A V T S L C F G R Y G R E D N T L I M T T R G G G L I I K I L K R T A M F V E G G S E V G P P P A Q A M K L N V P R K T R L Y V D Q T L R E R E A G T A M H R A F Q T D L Y L L R L R A A R A Y L Q A L E S S L S P L S T T A R E P L K L H A V V Q G L G P T F K L T L H L Q N T S T T R P V L G L L V C F L Y N E A L Y S L P R A F F K V P L L V P G L N Y P L E T F V E S L S N K G I S D I I K V G P A L V P R G R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).
Alternative names
BBS2L2, BBS1, BBSome complex member BBS1, BBS2-like protein 2, Bardet-Biedl syndrome 1 protein
Recommended products
Recombinant Human BBS1 protein is a Human Full Length protein, in the 1 to 463 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q8NFJ9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M S P G P Q L W H L L Q A L V S M C I R I S D P T S S S A Y P N C L Q I L W N K T F G T R P K R E T A E E P L S I Q S L R F L Q L E L S E M E A F V N Q H K S N S I K R Q T V I T T M T T L K K N L A D E D A V S C L V L G T E N K E L L V L D P E A F T I L A K M S L P S V P V F L E V S G Q F D V E F R L A A A C R N G N I Y I L R R D S K H P K Y C I E L S A Q P V G L I R V H K V L V V G S T Q D S L H G F T H K G K K L W T V Q M P A A I L T M N L L E Q H S R G L Q A V M A G L A N G E V R I Y R D K A L L N V I H T P D A V T S L C F G R Y G R E D N T L I M T T R G G G L I I K I L K R T A M F V E G G S E V G P P P A Q A M K L N V P R K T R L Y V D Q T L R E R E A G T A M H R A F Q T D L Y L L R L R A A R A Y L Q A L E S S L S P L S T T A R E P L K L H A V V Q G L G P T F K L T L H L Q N T S T T R P V L G L L V C F L Y N E A L Y S L P R A F F K V P L L V P G L N Y P L E T F V E S L S N K G I S D I I K V G P A L V P R G R
- Accession
- Q8NFJ9
- Protein length
- Full Length
- Amino acids
- 1 to 463
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (PubMed:17574030, PubMed:22072986). Plays a role in olfactory cilium biogenesis/maintenance and trafficking (By similarity).
- Subcellular localisation
- Cytoskeleton, Microtubule organizing center, Centrosome, Centriolar satellite
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human BBS1 protein (ab157954)
ab157954 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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