JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB139228

Recombinant Human BCL2L10 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human BCL2L10 protein is a Human Fragment protein, in the 1 to 172 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

BCL-B, BCLB, BOO, DIVA, BCL2L10, Bcl-2-like protein 10, Bcl2-L-10, Anti-apoptotic protein Boo, Anti-apoptotic protein NrH, Apoptosis regulator Bcl-B

1 Images
SDS-PAGE - Recombinant Human BCL2L10 protein (AB139228)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human BCL2L10 protein (AB139228)

15% SDS-PAGE analysis of 3 μg ab139228.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9HD36

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRT","proteinLength":"Fragment","predictedMolecularWeight":"21.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":172,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HD36","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column
style
left-column

Specifications

Form

Liquid

Additional notes

ab139228 is purified using conventional chromatography techniques.

style
left-column

General info

Function

Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed : 11278245, PubMed : 11689480). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed : 27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed : 27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed : 27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity).

Sequence similarities

Belongs to the Bcl-2 family.

Post-translational modifications

Monoubiquitinated by UBQLN1; results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm.

Subcellular localisation

Mitochondrion

style
left-column

Product protocols

style
left-column

Target data

Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed : 11278245, PubMed : 11689480). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed : 27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed : 27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed : 27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity).
See full target information BCL2L10
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB290060

Recombinant Human BCL2 Protein

Mass Spectrometry - Recombinant Human BCL2 Protein (AB290060)

  • 0
  • 0
Proteins & Peptides

AB151806

Recombinant Human Bcl2L2 protein

  • 0
  • 0
Primary Antibodies

AB233641

Anti-BCL2L10 antibody [8A2F9]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BCL2L10 antibody [8A2F9] (AB233641)

  • 0
  • 0
Primary Antibodies

AB192815

Anti-Caspase-9 (phospho T125) antibody

Western blot - Anti-Caspase-9 (phospho T125) antibody (AB192815)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com