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AB152226

Recombinant Human Bcl3 protein

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Recombinant Human Bcl3 protein is a Human Full Length protein, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

BCL4, D19S37, BCL3, B-cell lymphoma 3 protein, BCL-3, Proto-oncogene BCL3

1 Images
SDS-PAGE - Recombinant Human Bcl3 protein (AB152226)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Bcl3 protein (AB152226)

12.5% SDS-PAGE analysis of ab152226 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

P20749

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS","proteinLength":"Full Length","predictedMolecularWeight":"73.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P20749","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Bcl3 protein also known as Bcl-3 is a member of the IκB family of proteins. It serves a mechanical role as a transcription coactivator that interacts with NF-κB p50 and p52 homodimers. The Bcl3 protein has a molecular weight of approximately 45 kDa. This protein expresses primarily in lymphoid tissues including spleen and lymph nodes usually found within the nucleus where it performs its function in regulating gene expression.
Biological function summary

Bcl3 interacts with specific components of the NF-κB complex and modulates signaling pathways involved in immune responses inflammation and cell proliferation. Bcl3 helps in the stabilization and activation of p50/p52 dimers which facilitate the transcription of target genes. Its role necessitates its function within larger complexes that are essential for transcriptional regulation. Bcl3's interaction with other transcription factors allows it to fine-tune the expression of a range of genes impacting several cellular processes.

Pathways

Bcl3 plays a significant role in the regulation of the NF-κB signaling pathway. It acts by modulating the activity of NF-κB dimers important for immune response and inflammation. Furthermore it affects the PI3K/Akt pathway by influencing the expression of genes that are relevant to cell survival and apoptosis. Proteins such as p50 and p52 in the NF-κB pathway closely relate to Bcl3 function highlighting its role in cellular signaling networks.

Bcl3 is linked to certain types of cancers and autoimmune diseases. Its abnormal expression associates with disorders like chronic lymphocytic leukemia where it may contribute to disease progression by affecting cell proliferation and survival. Bcl3's interaction with NF-κB components can also influence rheumatoid arthritis where it might play a part in exacerbating inflammation. Proteins such as p50 and other NF-κB pathway components connect Bcl3 to these diseases reflecting its importance in disease mechanisms.
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Specifications

Form

Liquid

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General info

Function

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).

Post-translational modifications

Polyubiquitinated. Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Deubiquitination by CYLD prevents nuclear accumulation (By similarity).. Activated by phosphorylation.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity).
See full target information BCL3
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Complementary Products

Primary Antibodies

AB278529

Anti-Bcl3 antibody [EPR23835-115] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Bcl3 antibody [EPR23835-115] - BSA and Azide free (AB278529)

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