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AB152676

Recombinant Human beta Sarcoglycan protein (GST tag N-Terminus)

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Recombinant Human beta Sarcoglycan protein is a Human Full Length protein, in the 1 to 318 aa range, expressed in Wheat germ and suitable for western blot, SDS-PAGE and ELISA. The predicted molecular weight of ab152676 protein is 60.7 kDa.

- Save time and ensure accurate results - use our Human beta Sarcoglycan (SGCB) as a control

View Alternative Names

Beta-sarcoglycan, Beta-SG, 43 kDa dystrophin-associated glycoprotein, A3b, 43DAG, SGCB

1 Images
SDS-PAGE - Recombinant Human beta Sarcoglycan protein (GST tag N-Terminus) (AB152676)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human beta Sarcoglycan protein (GST tag N-Terminus) (AB152676)

12.5% SDS-PAGE analysis of ab152676 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA, SDS-PAGE

applications

Biologically active

No

Accession

Q16585

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB132339

Recombinant Human alpha Sarcoglycan protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human alpha Sarcoglycan protein (GST tag N-Terminus) (AB132339)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB315387

Anti-beta Sarcoglycan antibody [EPR28175-77] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Sarcoglycan antibody [EPR28175-77] - BSA and Azide free (AB315387)

  • 0
  • 0
Proteins & Peptides

AB165467

Recombinant Human ZBTB46 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZBTB46 protein (GST tag N-Terminus) (AB165467)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Ensure the validity of your result using our recombinant human beta Sarcoglycan (SGCB) protein ab152676 as a positive control in SDS-PAGE and western blot.

Analyze your Beta-SG ELISA data using the ab152676 protein to generate and plot a standard curve.



Check out our protein gel staining guide for SDS-PAGE here

Check out our western blot protocol for more information here

Check out our ELISA protocol for more information here.
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Sequence info

[{"sequence":"MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH","proteinLength":"Full Length","predictedMolecularWeight":"60.72 kDa","actualMolecularWeight":null,"aminoAcidEnd":318,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q16585","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Beta Sarcoglycan is a glycoprotein that has different names including 35DAG or A3b. It plays an important role in muscle cells by integrating into the sarcoglycan complex. This protein has an approximate mass of 43 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Beta Sarcoglycan provides structural support to the muscle cell membrane by linking inside the dystrophin-associated glycoprotein complex (DGC).
Biological function summary

Beta Sarcoglycan acts to maintain the stability of the muscle cell's sarcolemma. It forms part of the sarcoglycan complex which is one component of a larger dystrophin-glycoprotein complex. This complex protects muscle fibers from the stress of contraction. By ensuring the integrity of the muscle membrane Beta Sarcoglycan contributes to muscle fiber repair and regeneration reducing the risk of damage from repetitive use.

Pathways

Beta Sarcoglycan belongs to the dystrophin-associated glycoprotein complex playing a role in the linkage between the cytoskeleton and extracellular matrix. This involvement occurs primarily in the DGC signaling pathway. The interaction with dystrophin and other sarcoglycans ensures effective signal transduction and mechanical stability during muscle contraction. It relates to proteins including dystrophin itself and other sarcoglycans like alpha and gamma that cooperate in the same pathway.

Beta Sarcoglycan connects closely to limb-girdle muscular dystrophy (LGMD). Mutations in the gene encoding this protein lead to muscle weakness and degeneration characteristic of LGMD. It has a direct relationship with other sarcoglycans like gamma and alpha as defects in these proteins can cause similar dystrophic conditions. The impaired function of Beta Sarcoglycan results in the breakdown of muscle membrane integrity contributing to the progression of the disease.
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Specifications

Form

Liquid

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General info

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Sequence similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Post-translational modifications

Disulfide bonds are present.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
See full target information SGCB
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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