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AB202169

Recombinant Human beta Sarcoglycan protein

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Recombinant Human beta Sarcoglycan protein is a Human Fragment protein, in the 87 to 318 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Beta-sarcoglycan, Beta-SG, 43 kDa dystrophin-associated glycoprotein, A3b, 43DAG, SGCB

1 Images
SDS-PAGE - Recombinant Human beta Sarcoglycan protein (AB202169)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human beta Sarcoglycan protein (AB202169)

15% SDS-PAGE analysis of 3 μg ab202169.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q16585

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH","proteinLength":"Fragment","predictedMolecularWeight":"27.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":318,"aminoAcidStart":87,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q16585","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Beta Sarcoglycan is a glycoprotein that has different names including 35DAG or A3b. It plays an important role in muscle cells by integrating into the sarcoglycan complex. This protein has an approximate mass of 43 kDa. It is mainly expressed in skeletal and cardiac muscle tissues. Beta Sarcoglycan provides structural support to the muscle cell membrane by linking inside the dystrophin-associated glycoprotein complex (DGC).
Biological function summary

Beta Sarcoglycan acts to maintain the stability of the muscle cell's sarcolemma. It forms part of the sarcoglycan complex which is one component of a larger dystrophin-glycoprotein complex. This complex protects muscle fibers from the stress of contraction. By ensuring the integrity of the muscle membrane Beta Sarcoglycan contributes to muscle fiber repair and regeneration reducing the risk of damage from repetitive use.

Pathways

Beta Sarcoglycan belongs to the dystrophin-associated glycoprotein complex playing a role in the linkage between the cytoskeleton and extracellular matrix. This involvement occurs primarily in the DGC signaling pathway. The interaction with dystrophin and other sarcoglycans ensures effective signal transduction and mechanical stability during muscle contraction. It relates to proteins including dystrophin itself and other sarcoglycans like alpha and gamma that cooperate in the same pathway.

Beta Sarcoglycan connects closely to limb-girdle muscular dystrophy (LGMD). Mutations in the gene encoding this protein lead to muscle weakness and degeneration characteristic of LGMD. It has a direct relationship with other sarcoglycans like gamma and alpha as defects in these proteins can cause similar dystrophic conditions. The impaired function of Beta Sarcoglycan results in the breakdown of muscle membrane integrity contributing to the progression of the disease.
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Specifications

Form

Liquid

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General info

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Sequence similarities

Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Post-translational modifications

Disulfide bonds are present.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
See full target information SGCB
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