Recombinant Human beta Synuclein protein is a Human Full Length protein, in the 1 to 134 aa range, expressed in Escherichia coli, with >95% purity and suitable for WB, SDS-PAGE.
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- Biochemistry 51:4743-542012γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIrina Surgucheva et. al.PubMed 22620680
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
WB, SDS-PAGE
- Biologically active
No
Amino acid sequence
M D V F M K G L S M A K E G V V A A A E K T K Q G V T E A A E K T K E G V L Y V G S K T R E G V V Q G V A S V A E K T K E Q A S H L G G A V F S G A G N I A A A T G L V K R E E F P T D L K P E E V A Q E A A E E P L I E P L M E P E G E S Y E D P P Q E E Y Q E Y E P E A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application WB | Reactivity Reacts | Dilution info - | Notes ab48853 can be used as a WB positive control in conjunction with ab25650. |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes Predicted molecular weight 14 kda; molecular size on SDS-PAGE will be higher. |
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Target data
Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Alternative names
Beta-synuclein, SNCB
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Recombinant Human beta Synuclein protein is a Human Full Length protein, in the 1 to 134 aa range, expressed in Escherichia coli, with >95% purity and suitable for WB, SDS-PAGE.
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
WB, SDS-PAGE
- Biologically active
No
- Accession
- Q16143-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.5
Constituents: 0.58% Sodium chloride, 0.316% Tris HCl, 0.0095% Magnesium chloride
Sequence info
Amino acid sequence
M D V F M K G L S M A K E G V V A A A E K T K Q G V T E A A E K T K E G V L Y V G S K T R E G V V Q G V A S V A E K T K E Q A S H L G G A V F S G A G N I A A A T G L V K R E E F P T D L K P E E V A Q E A A E E P L I E P L M E P E G E S Y E D P P Q E E Y Q E Y E P E A
- Accession
- Protein length
Full Length
- Amino acids
1 to 134
- Nature
Recombinant
Specifications
- Form
Liquid
General info
- Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
- Sequence similarities
Belongs to the synuclein family.
- Post-translational modifications
Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Beta-synuclein also known as β-synuclein or SNCB is a protein that plays a role in the nervous system. It is a small protein with a molecular weight around 14 kDa. Predominantly beta-synuclein is found in presynaptic terminals of neurons in the central nervous system including the brain and spinal cord. This protein shares significant amino acid sequence identity with alpha-synuclein and gamma-synuclein comprising the synuclein family. It acts as a modulator of neuronal and synaptic function influencing the dynamics of neurotransmitter release.
- Biological function summary
Beta-synuclein contributes to cellular homeostasis and synaptic integrity. It is not typically found as part of a larger protein complex like its relative alpha-synuclein which forms toxic aggregates. Instead beta-synuclein exhibits neuroprotective properties helping maintain neuronal health. It possibly regulates synaptic vesicle cycling and mitigates levels of alpha-synuclein aggregation. Research suggests that loss of beta-synuclein function might disrupt synaptic stability leading to neurological issues.
- Pathways
Beta-synuclein engages in synaptic function and plasticity. It participates in pathways related to neurotransmitter release and synaptic vesicle trafficking. Beta-synuclein is connected to calcium/calmodulin-dependent protein kinase II (CaMKII) pathways. This interaction supports beta-synuclein's regulatory impact on synaptic vesicle dynamics negatively modulating the aggregation-prone behaviors seen in alpha-synuclein during synucleinopathies.
- Associated diseases and disorders
Beta-synuclein plays a role in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Research highlights its relationship with these conditions due to its interaction with alpha-synuclein known to form pathological aggregates and contribute to disease progression. Beta-synuclein's modulation of alpha-synuclein activity can impact the development and progression of these disorders. There is ongoing interest in its potential protective role suggesting it might be leveraged in therapeutic strategies against synucleinopathy-related diseases.
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SDS-PAGE - Recombinant Human beta Synuclein protein (ab48853)
ab48853 in 15%SDS-PAGE.
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