Recombinant Human Bex1 protein is a Human Full Length protein, in the 1 to 125 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M E S K E K R A V N S L S M E N A N Q E N E E K E Q V A N K G E P L A L P L D A G E Y C V P R G N R R R F R V R Q P I L Q Y R W D M M H R L G E P Q A R M R E E N M E R I G E E V R Q L M E K L R E K Q L S H S L R A V S T D P P H H D H H D E F C L M P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
Alternative names
Protein BEX1, Brain-expressed X-linked protein 1, BEX1
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Recombinant Human Bex1 protein is a Human Full Length protein, in the 1 to 125 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9HBH7-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M E S K E K R A V N S L S M E N A N Q E N E E K E Q V A N K G E P L A L P L D A G E Y C V P R G N R R R F R V R Q P I L Q Y R W D M M H R L G E P Q A R M R E E N M E R I G E E V R Q L M E K L R E K Q L S H S L R A V S T D P P H H D H H D E F C L M P
- Accession
- Q9HBH7
- Protein length
- Full Length
- Predicted molecular weight
- 17.2 kDa
- Amino acids
- 1 to 125
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab167840 was purified using conventional chromatography techniques.
General info
- Function
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
- Sequence similarities
Belongs to the BEX family.
- Post-translational modifications
Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Bex1 also known as Brain Expressed X-linked 1 is a protein primarily involved in cellular processes such as cell cycle regulation and apoptosis. It has a molecular mass of approximately 14 kDa. Bex1 shows expression mainly in the brain but it can also be found in other tissues such as the testis and liver. Its location and size suggest a highly specialized role in cellular signaling and function.
- Biological function summary
Bex1 interacts with components of the signaling pathways to regulate neuronal differentiation and survival. It can form part of a protein complex that affects transcription factors leading to modifications in gene expression profiles. By influencing these activities Bex1 plays an important role in maintaining normal neurological function and development.
- Pathways
The role of Bex1 integrates into neurotrophic signaling and MAP kinase pathways. This protein is linked with brain-derived neurotrophic factor (BDNF) signaling affecting neuronal growth and plasticity. Bex1 is also associated with mitogen-activated protein kinases (MAPKs) which are critical in processes such as synaptic transmission and neuronal differentiation. Through these pathways Bex1 maintains interactions with various proteins ensuring effective signal transduction in neural tissues.
- Associated diseases and disorders
Altered expression or mutations of Bex1 have been implicated in neurodegenerative diseases and certain cancers. In Alzheimer's disease Bex1's connection with BDNF signaling reveals its potential involvement in neurodegeneration and loss of cognitive function. Additionally its modulation of apoptosis pathways raises interest in studying Bex1 in brain cancers where it may affect tumor growth and resistance. In these contexts Bex1’s role in regulating critical proteins like BDNF highlights its importance in disease mechanisms.
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1 product image
SDS-PAGE - Recombinant Human Bex1 protein (ab167840)
15% SDS-PAGE analysis of ab167840 (3 µg).
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