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AB167840

Recombinant Human Bex1 protein (His tag N-Terminus)

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Recombinant Human Bex1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 125 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Protein BEX1, Brain-expressed X-linked protein 1, BEX1

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SDS-PAGE - Recombinant Human Bex1 protein (His tag N-Terminus) (AB167840)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Bex1 protein (His tag N-Terminus) (AB167840)

15% SDS-PAGE analysis of ab167840 (3 µg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9HBH7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP","proteinLength":"Full Length","predictedMolecularWeight":"17.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":125,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HBH7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Bex1 also known as Brain Expressed X-linked 1 is a protein primarily involved in cellular processes such as cell cycle regulation and apoptosis. It has a molecular mass of approximately 14 kDa. Bex1 shows expression mainly in the brain but it can also be found in other tissues such as the testis and liver. Its location and size suggest a highly specialized role in cellular signaling and function.
Biological function summary

Bex1 interacts with components of the signaling pathways to regulate neuronal differentiation and survival. It can form part of a protein complex that affects transcription factors leading to modifications in gene expression profiles. By influencing these activities Bex1 plays an important role in maintaining normal neurological function and development.

Pathways

The role of Bex1 integrates into neurotrophic signaling and MAP kinase pathways. This protein is linked with brain-derived neurotrophic factor (BDNF) signaling affecting neuronal growth and plasticity. Bex1 is also associated with mitogen-activated protein kinases (MAPKs) which are critical in processes such as synaptic transmission and neuronal differentiation. Through these pathways Bex1 maintains interactions with various proteins ensuring effective signal transduction in neural tissues.

Altered expression or mutations of Bex1 have been implicated in neurodegenerative diseases and certain cancers. In Alzheimer's disease Bex1's connection with BDNF signaling reveals its potential involvement in neurodegeneration and loss of cognitive function. Additionally its modulation of apoptosis pathways raises interest in studying Bex1 in brain cancers where it may affect tumor growth and resistance. In these contexts Bex1’s role in regulating critical proteins like BDNF highlights its importance in disease mechanisms.
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Specifications

Form

Liquid

Additional notes

ab167840 was purified using conventional chromatography techniques.

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General info

Function

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex : associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).

Sequence similarities

Belongs to the BEX family.

Post-translational modifications

Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome.. Ubiquitinated. Degraded by the proteasome.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex : associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity).
See full target information BEX1
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