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AB162491

Recombinant Human BFAR protein (GST tag N-Terminus)

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Recombinant Human BFAR protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 450 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

BAR, RNF47, BFAR, Bifunctional apoptosis regulator, RING finger protein 47

1 Images
SDS-PAGE - Recombinant Human BFAR protein (GST tag N-Terminus) (AB162491)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human BFAR protein (GST tag N-Terminus) (AB162491)

ab162491 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9NZS9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MEEPQKSYVNTMDLERDEPLKSTGPQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWASSKKTECPECREKWEGFPKVSILLRDAIEKLFPDAIRLRFEDIQQNNDIVQSLAAFQKYGNDQIPLAPNTGRANQQMGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKAVAKWTAEEVVLWLEQLGPWASLYRERFLSERVNGRLLLTLTEEEFSKTPYTIENSSHRRAILMELERVKALGVKPPQNLWEYKAVNPGRSLFLLYALKSSPRLSLLYLYLFDYTDTFLPFIHTICPLQEDSSGEDIVTKLLDLKEPTWKQWREFLVKYSFLPYQLIAEFAWDWLEVHYWTSRFLIINAMLLSVLELFSFWRIWSRSELKTVPQRMWSHFWKVSTQGLFVAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKELRRLETQVL","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":450,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9NZS9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

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General info

Function

Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress (PubMed : 14502241, PubMed : 21068390). Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (PubMed : 14502241). Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation (PubMed : 21068390). Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway (PubMed : 33914044). Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed : 22566094). Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism (PubMed : 38294943).

Post-translational modifications

Mediates RING-dependent self-ubiquitination leading to proteasomal degradation.

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Product protocols

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Target data

Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress (PubMed : 14502241, PubMed : 21068390). Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (PubMed : 14502241). Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation (PubMed : 21068390). Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway (PubMed : 33914044). Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed : 22566094). Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism (PubMed : 38294943).
See full target information BFAR
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