Recombinant Human Biglycan protein (His tag) is a Human Full Length protein, in the 38 to 368 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
D E E A S G A D T S G V L D P D S V T P T Y S A M C P F G C H C H L R V V Q C S D L G L K S V P K E I S P D T T L L D L Q N N D I S E L R K D D F K G L Q H L Y A L V L V N N K I S K I H E K A F S P L R K L Q K L Y I S K N H L V E I P P N L P S S L V E L R I H D N R I R K V P K G V F S G L R N M N C I E M G G N P L E N S G F E P G A F D G L K L N Y L R I S E A K L T G I P K D L P E T L N E L H L D H N K I Q A I E L E D L L R Y S K L Y R L G L G H N Q I R M I E N G S L S F L P T L R E L H L D N N K L A R V P S G L P D L K L L Q V V Y L H S N N I T K V G V N D F C P M G F G V K R A Y Y N G I S L F N N P V P Y W E V Q P A T F R C V T D R L A I Q F G N Y K K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
Biglycan, Bone/cartilage proteoglycan I, PG-S1, SLRR1A, BGN
Recommended products
Recombinant Human Biglycan protein (His tag) is a Human Full Length protein, in the 38 to 368 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Alternative names
Biglycan, Bone/cartilage proteoglycan I, PG-S1, SLRR1A, BGN
Key facts
- Purity
>95% SDS-PAGE
- Endotoxin level
< 1 EU/µg
- Expression system
HEK 293 cells
- Tags
His tag C-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- P21810-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
D E E A S G A D T S G V L D P D S V T P T Y S A M C P F G C H C H L R V V Q C S D L G L K S V P K E I S P D T T L L D L Q N N D I S E L R K D D F K G L Q H L Y A L V L V N N K I S K I H E K A F S P L R K L Q K L Y I S K N H L V E I P P N L P S S L V E L R I H D N R I R K V P K G V F S G L R N M N C I E M G G N P L E N S G F E P G A F D G L K L N Y L R I S E A K L T G I P K D L P E T L N E L H L D H N K I Q A I E L E D L L R Y S K L Y R L G L G H N Q I R M I E N G S L S F L P T L R E L H L D N N K L A R V P S G L P D L K L L Q V V Y L H S N N I T K V G V N D F C P M G F G V K R A Y Y N G I S L F N N P V P Y W E V Q P A T F R C V T D R L A I Q F G N Y K K
- Accession
- Protein length
Full Length
- Predicted molecular weight
38.7 kDa
- Amino acids
38 to 368
- Nature
Recombinant
- Tags
His tag C-Terminus
Specifications
- Form
Lyophilized
General info
- Function
May be involved in collagen fiber assembly.
- Sequence similarities
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
- Post-translational modifications
The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Biglycan also known as BGN is a small leucine-rich proteoglycan with a molecular weight of roughly 38 kDa. Researchers frequently observe Biglycan in tissues such as bone cartilage and vasculature. The protein interacts with several other molecules in the extracellular matrix (ECM) including collagen and elastin to maintain the structural integrity of tissues. Through these interactions Biglycan plays an important role in supporting cell attachment and matrix organization.
- Biological function summary
The protein Biglycan influences cellular processes such as growth and differentiation. It is part of a complex network within the ECM that modulates cell signaling. Biglycan interacts with growth factors like transforming growth factor-beta (TGF-beta) and binds to Toll-like receptors (TLRs) affecting immune responses. These capabilities reveal Biglycan’s involvement in tissue development and repair.
- Pathways
Extracellular matrix modulation shows a significant role for Biglycan. It is involved in the TGF-beta signaling pathway and the inflammatory pathway mediated by TLRs. Through these pathways Biglycan interacts with proteins such as decorin and fibromodulin contributing to the regulation of collagen fibrillogenesis and inflammatory responses. Its role in these pathways highlights Biglycan’s influence in cellular communication and matrix regulation.
- Associated diseases and disorders
Biglycan has associations with osteoarthritis and muscular dystrophy. In osteoarthritis researchers observe altered expression levels of Biglycan which affects cartilage integrity. In muscular dystrophy the protein’s connection to dystrophin an important structural protein is noted. These associations illustrate Biglycan's impact on disease progression and its potential as a therapeutic target.
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SDS-PAGE - Recombinant Human Biglycan protein (His tag) (ab276271)
SDS-PAGE analysis of ab276271
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