Recombinant Human BIN1 protein is a Human Full Length protein, in the 1 to 439 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M A E M G S K G V T A G K I A S N V Q K K L T R A Q E K V L Q K L G K A D E T K D E Q F E Q C V Q N F N K Q L T E G T R L Q K D L R T Y L A S V K A M H E A S K K L N E C L Q E V Y E P D W P G R D E A N K I A E N N D L L W M D Y H Q K L V D Q A L L T M D T Y L G Q F P D I K S R I A K R G R K L V D Y D S A R H H Y E S L Q T A K K K D E A K I A K A E E E L I K A Q K V F E E M N V D L Q E E L P S L W N S R V G F Y V N T F Q S I A G L E E N F H K E M S K L N Q N L N D V L V G L E K Q H G S N T F T V K A Q P S D N A P A K G N K S P S P P D G S P A A T P E I R V N H E P E P A G G A T P G A T L P K S P S Q P A E A S E V A G G T Q P A A G A Q E P G E T A A S E A A S S S L P A V V V E T F P A T V N G T V E G G S G A G R L D L P P G F M F K V Q A Q H D Y T A T D T D E L Q L R A G D V V L V I P F Q N P E E Q D E G W L M G V K E S D W N Q H K E L E K C R G V F P E N F T E R V P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
Alternative names
AMPHL, BIN1, Myc box-dependent-interacting protein 1, Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1
Recommended products
Recombinant Human BIN1 protein is a Human Full Length protein, in the 1 to 439 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- O00499-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M A E M G S K G V T A G K I A S N V Q K K L T R A Q E K V L Q K L G K A D E T K D E Q F E Q C V Q N F N K Q L T E G T R L Q K D L R T Y L A S V K A M H E A S K K L N E C L Q E V Y E P D W P G R D E A N K I A E N N D L L W M D Y H Q K L V D Q A L L T M D T Y L G Q F P D I K S R I A K R G R K L V D Y D S A R H H Y E S L Q T A K K K D E A K I A K A E E E L I K A Q K V F E E M N V D L Q E E L P S L W N S R V G F Y V N T F Q S I A G L E E N F H K E M S K L N Q N L N D V L V G L E K Q H G S N T F T V K A Q P S D N A P A K G N K S P S P P D G S P A A T P E I R V N H E P E P A G G A T P G A T L P K S P S Q P A E A S E V A G G T Q P A A G A Q E P G E T A A S E A A S S S L P A V V V E T F P A T V N G T V E G G S G A G R L D L P P G F M F K V Q A Q H D Y T A T D T D E L Q L R A G D V V L V I P F Q N P E E Q D E G W L M G V K E S D W N Q H K E L E K C R G V F P E N F T E R V P
- Accession
- O00499
- Protein length
- Full Length
- Predicted molecular weight
- 50.4 kDa
- Amino acids
- 1 to 439
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab98238 was purified using conventional chromatography techniques.
General info
- Function
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
- Post-translational modifications
Phosphorylated by protein kinase C.
- Subcellular localisation
- Nucleus, Endosome
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human BIN1 protein (ab98238)
15% SDS-PAGE analysis of 3μg ab98238
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- Visit the general protocols
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