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AB276230

Recombinant Human BMP5 protein (Fc Chimera)

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Recombinant Human BMP5 protein (Fc Chimera) is a Human Fragment protein, in the 324 to 454 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Bone morphogenetic protein 5, BMP-5, BMP5

1 Images
SDS-PAGE - Recombinant Human BMP5 protein (Fc Chimera) (AB276230)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human BMP5 protein (Fc Chimera) (AB276230)

SDS-PAGE analysis of ab276230

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P22003

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"QNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH","proteinLength":"Fragment","predictedMolecularWeight":"41.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":454,"aminoAcidStart":324,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P22003","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Lyophilized

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General info

Function

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed : 11580864, PubMed : 29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed : 11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed : 11580864, PubMed : 29321139). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed : 20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed : 30097509).

Sequence similarities

Belongs to the TGF-beta family.

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Product protocols

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Target data

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed : 11580864, PubMed : 29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed : 11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed : 11580864, PubMed : 29321139). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed : 20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed : 30097509).
See full target information Bone morphogenetic protein 5
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Product promise

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