Recombinant Human BMP7 protein is a Human Full Length protein, in the 293 to 431 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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- Cell research 27:1157-11772017Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHui Zhang et. al.PubMed 28809397
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S T G S K Q R S Q N R S K T P K N Q E A L R M A N V A E N S S S D Q R Q A C K K H E L Y V S F R D L G W Q D W I I A P E G Y A A Y Y C E G E C A F P L N S Y M N A T N H A I V Q T L V H F I N P E T V P K P C C A P T Q L N A I S V L Y F D D S S N V I L K K Y R N M V V R A C G C H L E H H H H H H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:12667445, PubMed:9748228). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509).
Alternative names
OP1, BMP7, Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1
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Recombinant Human BMP7 protein is a Human Full Length protein, in the 293 to 431 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P18075-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 3.5
Constituents: 10% Glycerol (glycerin, glycerine), 0.294% Sodium citrate
Sequence info
Amino acid sequence
- M S T G S K Q R S Q N R S K T P K N Q E A L R M A N V A E N S S S D Q R Q A C K K H E L Y V S F R D L G W Q D W I I A P E G Y A A Y Y C E G E C A F P L N S Y M N A T N H A I V Q T L V H F I N P E T V P K P C C A P T Q L N A I S V L Y F D D S S N V I L K K Y R N M V V R A C G C H L E H H H H H H
- Accession
- P18075
- Protein length
- Full Length
- Amino acids
- 293 to 431
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab87055 was purified using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.
General info
- Function
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:12667445, PubMed:9748228). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509).
- Sequence similarities
Belongs to the TGF-beta family.
- Post-translational modifications
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Endotoxin Level: < 1.0 EU per 1 µg of protein (determined by LAL method)
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1 product image
SDS-PAGE - Recombinant Human BMP7 protein (ab87055)
ab87055 on 15% SDS-PAGE (3μg)
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