Recombinant human BMP7 protein (Active) is a Human Fragment protein, in the 315 to 431 aa range, expressed in CHO, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
>98% SDS-PAGE
< 1 EU/µg
CHO cells
Tag free
SDS-PAGE, FuncS, HPLC
Yes
M A N V A E N S S S D Q R Q A C K K H E L Y V S F R D L G W Q D W I I A P E G Y A A Y Y C E G E C A F P L N S Y M N A T N H A I V Q T L V H F I N P E T V P K P C C A P T Q L N A I S V L Y F D D S S N V I L K K Y R N M V V R A C G C H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).
Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, BMP7, OP1
Recombinant human BMP7 protein (Active) is a Human Fragment protein, in the 315 to 431 aa range, expressed in CHO, with >98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
Bone morphogenetic protein 7, BMP-7, Osteogenic protein 1, OP-1, BMP7, OP1
>98% SDS-PAGE
< 1 EU/µg
CHO cells
Tag free
SDS-PAGE, FuncS, HPLC
Yes
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml.
No
Human
Reconstitute in water to 0.1 - 1.0 mg/ml.
M A N V A E N S S S D Q R Q A C K K H E L Y V S F R D L G W Q D W I I A P E G Y A A Y Y C E G E C A F P L N S Y M N A T N H A I V Q T L V H F I N P E T V P K P C C A P T Q L N A I S V L Y F D D S S N V I L K K Y R N M V V R A C G C H
Fragment
26.4 kDa
315 to 431
Recombinant
Lyophilized
Greater than 98% by HPLC analyses.
Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:31208997). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A (PubMed:9748228, PubMed:12667445). Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:12478285). For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor (PubMed:31208997). Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).
Belongs to the TGF-beta family.
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Migrates at an apparent molecular weight of approximately 25-35 kDa by SDS-PAGE analysis under non-reducing conditions.
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