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Recombinant human BMP9 protein (Active) is a Human Full Length protein, in the 320 to 429 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, HPLC.

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Key facts

Purity
>95% SDS-PAGE
Expression system
CHO cells
Tags
Tag free
Applications
SDS-PAGE, HPLC
Biologically active
Yes

Amino acid sequence

S A G A G S H C Q K T S L R V N F E D I G W D S W I I A P K E Y E A Y E C K G G C F F P L A D D V T P T K H A I V Q T L V H L K F P T K V G K A C C V P T K L S P I S V L Y K D D M G V P T L K Y H Y E G M S V A E C G C R

Reactivity data

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
HPLC
Reactivity
Reacts
Dilution info
-
Notes

-

Target data

Function

Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.

Alternative names

BMP9, GDF2, Growth/differentiation factor 2, GDF-2, Bone morphogenetic protein 9, BMP-9

Recommended products

Recombinant human BMP9 protein (Active) is a Human Full Length protein, in the 320 to 429 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, HPLC.

Key facts

Purity
>95% SDS-PAGE
Expression system
CHO cells
Applications
SDS-PAGE, HPLC
Biological activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml.
Accession
Q9UK05-1
Animal free
No
Species
Human
Concentration
Loading...

Sequence info

Amino acid sequence

S A G A G S H C Q K T S L R V N F E D I G W D S W I I A P K E Y E A Y E C K G G C F F P L A D D V T P T K H A I V Q T L V H L K F P T K V G K A C C V P T K L S P I S V L Y K D D M G V P T L K Y H Y E G M S V A E C G C R
Accession
Q9UK05
Protein length
Full Length
Predicted molecular weight
24.1 kDa
Amino acids
320 to 429
Nature
Recombinant

Specifications

Form
Lyophilized
Additional notes

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).

General info

Function

Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.

Sequence similarities

Belongs to the TGF-beta family.

Post-translational modifications

A reversible disulfide bond can be formed between the two subunits in the homodimer; this has no effect on GDF2 activity.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

This product is an active protein and may elicit a biological response in vivo, handle with caution.

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