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AB105907

Recombinant human BMPR1A protein

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Recombinant human BMPR1A protein is a Human Fragment protein, in the 187 to 532 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for WB, FuncS.

View Alternative Names

CD292, ACVRLK3, ALK3, BMPR1A, Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, Serine/threonine-protein kinase receptor R5, ALK-3, SKR5

4 Images
Functional Studies - Recombinant human BMPR1A protein (AB105907)
  • FuncS

Unknown

Functional Studies - Recombinant human BMPR1A protein (AB105907)

Kinase Assay demonstrating specific activity of ab105907 at 1.2 nmol/min/mg.

Functional Studies - Recombinant human BMPR1A protein (AB105907)
  • FuncS

Unknown

Functional Studies - Recombinant human BMPR1A protein (AB105907)

The specific activity of BMPR1A (ab105907) was determined to be 1.4 nmol/min/mg as per activity assay protocol

SDS-PAGE - Recombinant human BMPR1A protein (AB105907)
  • SDS-PAGE

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SDS-PAGE - Recombinant human BMPR1A protein (AB105907)

SDS-PAGE showing ab105907 at approximately 66kDa.

SDS-PAGE - Recombinant human BMPR1A protein (AB105907)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human BMPR1A protein (AB105907)

SDS PAGE analysis of ab105907

Key facts

Purity

>90% Densitometry

Expression system

Baculovirus infected Sf9 cells

Tags

Tag free

Applications

FuncS, WB

applications

Biologically active

Yes

Biological activity

The Specific activity of ab105907 was determined to be 1.2 nmol/min/mg.

Accession

P36894

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.307% Glutathione, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00292% EDTA, 0.00174% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"66 kDa","actualMolecularWeight":null,"aminoAcidEnd":532,"aminoAcidStart":187,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P36894","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Liquid

Additional notes

Purity was determined to be >90% by densitometry. Affinity purified.

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General info

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity).

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Post-translational modifications

Glycosylated.

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Product protocols

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Target data

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity).
See full target information BMPR1A
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