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AB107949

Recombinant human BMPR1B protein

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Recombinant human BMPR1B protein is a Human Fragment protein, in the 149 to 502 aa range, expressed in Baculovirus infected Sf9 cells, with >85%, suitable for SDS-PAGE, WB, FuncS.

View Alternative Names

CDw293, Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, BMPR1B

4 Images
Functional Studies - Recombinant human BMPR1B protein (AB107949)
  • FuncS

Unknown

Functional Studies - Recombinant human BMPR1B protein (AB107949)

Kinase Assay demonstrating specific activity of ab107949.

Functional Studies - Recombinant human BMPR1B protein (AB107949)
  • FuncS

Unknown

Functional Studies - Recombinant human BMPR1B protein (AB107949)

The specific activity of BMPR1B (ab107949) was determined to be 19 nmol/min/mg as per activity assay protocol

SDS-PAGE - Recombinant human BMPR1B protein (AB107949)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human BMPR1B protein (AB107949)

SDS PAGE analysis of ab107949

SDS-PAGE - Recombinant human BMPR1B protein (AB107949)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human BMPR1B protein (AB107949)

SDS-PAGE showing ab107949 at approximately 68kDa.

Key facts

Purity

>85% SDS-PAGE

Purity was determined to be >85% by densitometry. Affinity purified.

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, FuncS

applications

Biologically active

Yes

Biological activity

The Specific activity of ab107949 was determined to be 23 nmol/min/mg.

Accession

O00238

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.307% Glutathione, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00292% EDTA, 0.00174% PMSF

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Complementary Products

Primary Antibodies

AB78417

Anti-BMPR1B antibody [MM0055-3E12]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-BMPR1B antibody [MM0055-3E12] (AB78417)

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Assay Kits

AB309448

Human BMPR1B ELISA Kit

Recombinant

Sandwich ELISA - Human BMPR1B ELISA Kit (AB309448)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity
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Sequence info

[{"linker":null,"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"68 kDa","actualMolecularWeight":null,"aminoAcidEnd":502,"aminoAcidStart":149,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"O00238","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification
Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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General info

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Post-translational modifications

Autophosphorylated.

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Product protocols

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Target data

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
See full target information Bone morphogenetic protein receptor type-1B
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Product promise

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For full details, please see our Terms & Conditions

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