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AB202216

Recombinant Human BNIP1 protein (denatured) (His tag N-Terminus)

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Recombinant Human BNIP1 protein (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.

View Alternative Names

NIP1, SEC20L, TRG8, BNIP1, Vesicle transport protein SEC20, BCL2/adenovirus E1B 19 kDa protein-interacting protein 1, Transformation-related gene 8 protein, TRG-8

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SDS-PAGE - Recombinant Human BNIP1 protein (denatured) (AB202216)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human BNIP1 protein (denatured) (AB202216)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q12981

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSALTELNTKVKEKFQQLRHRIQDLEQLAKEQDKESEKQLLLQEVENHKKQMLSNQASWRKANLTCKIAIDNLEKAELLQGGDLLRQRKTTKESLAQTSSTITESLMGISRMMAQQVQQSEEAMQSLVTSSRTILDANEEFKSMSGTIQLGRKLITKYNRREL","proteinLength":"Fragment","predictedMolecularWeight":"25.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q12981","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab202216 was purified using conventional chromatography.

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General info

Function

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed : 15272311). Also plays a role in apoptosis (PubMed : 15272311, PubMed : 23896122, PubMed : 7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed : 23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).

Sequence similarities

Belongs to the SEC20 family.

Post-translational modifications

Polyubiquitinated (PubMed:21931693, PubMed:23896122). 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1 (PubMed:21931693). Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion (PubMed:23896122).

Subcellular localisation

Mitochondrion membrane

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Product protocols

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Target data

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed : 15272311). Also plays a role in apoptosis (PubMed : 15272311, PubMed : 23896122, PubMed : 7954800). It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed : 23896122). As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable).
See full target information BNIP1
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