Recombinant Human BNIP3L/NIX protein is a Human Fragment protein, in the 43 to 130 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
S S N G N D N G N G K N G G L E H V P S S S S I H N G D M E K I L L D A Q H E S G Q S S S R G S S H C D S P S P Q E D G Q I M F D V E M H T S R D H S S Q S E E E V V E G E K E
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
BNIP3A, BNIP3H, NIX, BNIP3H, NIX, BNIP3A, BNIP3L, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, NIP3-like protein X, NIP3L
Recombinant Human BNIP3L/NIX protein is a Human Fragment protein, in the 43 to 130 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
S S N G N D N G N G K N G G L E H V P S S S S I H N G D M E K I L L D A Q H E S G Q S S S R G S S H C D S P S P Q E D G Q I M F D V E M H T S R D H S S Q S E E E V V E G E K E
Fragment
35.31 kDa
43 to 130
Recombinant
Liquid
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Belongs to the NIP3 family.
Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
Nucleus envelope, Mitochondrion outer membrane
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product was previously labelled as BNIP3L.
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ab114290 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.
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