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Recombinant Human BNIP3L/NIX protein is a Human Fragment protein, in the 43 to 130 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

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Images

SDS-PAGE - Recombinant Human BNIP3L/NIX protein (AB114290), expandable thumbnail

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

SDS-PAGE, ELISA, WB

Biologically active

No

Amino acid sequence

S S N G N D N G N G K N G G L E H V P S S S S I H N G D M E K I L L D A Q H E S G Q S S S R G S S H C D S P S P Q E D G Q I M F D V E M H T S R D H S S Q S E E E V V E G E K E

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

ELISA

Reactivity

Reacts

Dilution info

-

Notes

-

Application

WB

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Alternative names

Recommended products

Recombinant Human BNIP3L/NIX protein is a Human Fragment protein, in the 43 to 130 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

Key facts

Expression system

Wheat germ

Applications

SDS-PAGE, ELISA, WB

Accession
O60238-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione

Sequence info

Amino acid sequence

S S N G N D N G N G K N G G L E H V P S S S S I H N G D M E K I L L D A Q H E S G Q S S S R G S S H C D S P S P Q E D G Q I M F D V E M H T S R D H S S Q S E E E V V E G E K E

Accession

O60238

Protein length

Fragment

Predicted molecular weight

35.31 kDa

Amino acids

43 to 130

Nature

Recombinant

Specifications

Form

Liquid

General info

Function

Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.

Sequence similarities

Belongs to the NIP3 family.

Post-translational modifications

Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.

Subcellular localisation

Nucleus envelope, Mitochondrion outer membrane

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

This product was previously labelled as BNIP3L.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • SDS-PAGE - Recombinant Human BNIP3L/NIX protein (ab114290), expandable thumbnail

    SDS-PAGE - Recombinant Human BNIP3L/NIX protein (ab114290)

    ab114290 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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