Recombinant Human BNP protein is a Human Fragment protein, in the 27 to 132 aa range, expressed in Escherichia coli, with >85% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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- Nature communications 14:53642023DNA nanopores as artificial membrane channels for bioprotonics.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLe Luo,Swathi Manda,Yunjeong Park,Busra Demir,Jesse Sanchez,M P Anantram,Ersin Emre Oren,Ashwin Gopinath,Marco RolandiPubMed 37666808
- Nature chemistry 15:773-7802023A high-dimensional microfluidic approach for selection of aptamers with programmable binding affinities.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDingran Chang,Zongjie Wang,Connor D Flynn,Alam Mahmud,Mahmoud Labib,Hansen Wang,Armin Geraili,Xiangling Li,Jiaqi Zhang,Edward H Sargent,Shana O KelleyPubMed 37277648
- Microsystems & nanoengineering 7:512021Low limit of detection of the AlGaN/GaN-based sensor by the Kelvin connection detection technique.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHanyuan Zhang,Ying Gan,Shu Yang,Kuang Sheng,Ping WangPubMed 34567764
- Matter 3:1981-19982020SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRebeca M Torrente-Rodríguez et. al.PubMed 33043291
Key facts
- Purity
- >85% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M H P L G S P G S A S D L E T S G L Q E Q R N H L Q G K L S E L Q V E Q T S L E P L Q E S P R P T G V W K S R E V A T E G I R G H R K M V L Y T L R A P R S P K M V Q G S G C F G R K M D R I S S S S G L G C K V L R R H
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Brain natriuretic peptide 32. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed:1672777, PubMed:17372040, PubMed:1914098, PubMed:9458824). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed:1672777, PubMed:17349887, PubMed:17372040, PubMed:21098034, PubMed:25339504, PubMed:9458824). Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion (PubMed:1914098, PubMed:9458824). Binds the clearance receptor NPR3 (PubMed:16870210). NT-proBNP. May affect cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP although its potency is very low compared to brain natriuretic peptide 32 (PubMed:17372040). BNP(3-32). May have a role in cardio-renal homeostasis (PubMed:17372040). Able to promote the production of cGMP (PubMed:17372040).
Additional Targets
BNP
Alternative names
Natriuretic peptides B, Brain natriuretic factor prohormone, Gamma-brain natriuretic peptide, Iso-ANP, preproBNP, proBNP, NPPB
Recommended products
Recombinant Human BNP protein is a Human Fragment protein, in the 27 to 132 aa range, expressed in Escherichia coli, with >85% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P16860-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.029% EDTA, 0.002% PMSF
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M H P L G S P G S A S D L E T S G L Q E Q R N H L Q G K L S E L Q V E Q T S L E P L Q E S P R P T G V W K S R E V A T E G I R G H R K M V L Y T L R A P R S P K M V Q G S G C F G R K M D R I S S S S G L G C K V L R R H
- Accession
- P16860
- Protein length
- Fragment
- Predicted molecular weight
- 14 kDa
- Actual molecular weight
- 14 kDa
- Amino acids
- 27 to 132
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab87200 is purified using conventional chromatography techniques.
General info
- Function
Brain natriuretic peptide 32
- Sequence similarities
Belongs to the natriuretic peptide family.
- Post-translational modifications
The precursor molecule is proteolytically cleaved by the endoproteases FURIN or CORIN at Arg-102 to produce brain natriuretic peptide 32 and NT-proBNP (PubMed:10880574, PubMed:20489134, PubMed:21314817, PubMed:21482747, PubMed:21763278). This likely occurs after it has been secreted into the blood, either during circulation or in the target cells (PubMed:21482747). CORIN also cleaves the precursor molecule at additional residues including Arg-99 and possibly Lys-105 (PubMed:20489134, PubMed:21763278). In patients with heart failure, processing and degradation of natriuretic peptides B occurs but is delayed, possibly due to a decrease in enzyme level or activity of CORIN and DPP4 (PubMed:25339504).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human BNP protein (ab87200)
15% SDS-PAGE showing ab87200 at approximately 14kDa (3μg).
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