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AB276457

Recombinant Human Brorin protein (His tag)

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Recombinant Human Brorin protein (His tag) is a Human Full Length protein, in the 1 to 325 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

UNQ739/PRO1434, VWC2, Brorin, Brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2

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SDS-PAGE - Recombinant Human Brorin protein (His tag) (AB276457)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Brorin protein (His tag) (AB276457)

SDS-PAGE analysis of ab276457

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q2TAL6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPSSTAMAVGALSSSLLVTCCLMVALCSPSIPLEKLAQAPEQPGQEKREHASRDGPGRVNELGRPARDEGGSGRDWKSKSGRGLAGREPWSKLKQAWVSQGGGAKAGDLQVRPRGDTPQAEALAAAAQDAIGPELAPTPEPPEEYVYPDYRGKGCVDESGFVYAIGEKFAPGPSACPCLCTEEGPLCAQPECPRLHPRCIHVDTSQCCPQCKERKNYCEFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQTECVDPVYEPDQCCPICKNGPNCFAETAVIPAGREVKTDECTICHCTYEEGTWRIERQAMCTRHECRQM","proteinLength":"Full Length","predictedMolecularWeight":"34.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":325,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q2TAL6","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Brorin also known as VSTM2L is a protein that plays a role in the regulation of cellular and developmental processes. It has a molecular mass of approximately 48 kDa. Brorin is expressed highly in the central nervous system particularly within the brain. Its expression is important for maintaining neural developmental processes and is thought to influence neurogenesis and neuronal differentiation.
Biological function summary

Brorin acts as an antagonist for bone morphogenetic proteins (BMPs) which are part of the transforming growth factor-beta (TGF-β) superfamily. By inhibiting BMP signaling Brorin modulates the activity of this complex signaling pathway. This inhibition affects processes like neural tube closure and the patterning of the dorsal-ventral axis in neural development. Brorin's role as a negative regulator of BMP activity suggests its importance in maintaining precise control over developmental timing and cellular differentiation in the nervous system.

Pathways

Brorin interacts significantly with the BMP signaling pathway. This pathway is essential in regulating embryonic development and cellular growth. Brorin's modulation of BMP activity impacts the pathway's influences on neural development and tissue homeostasis. It has connections with proteins such as noggin and chordin which are also known to inhibit BMP signaling and are involved in similar regulatory processes during development.

Brorin has associations with neurological conditions such as neurodegenerative diseases and developmental disorders. Anomalies in BMP signaling due to altered Brorin levels can lead to improper neural development and diseases like Alzheimer's. Through its interaction with BMP-related proteins including noggin disruptions can result in irregular neuron function and contribute to neuropathological conditions. Understanding Brorin's role provides insights into therapeutic targets for these disorders.
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Specifications

Form

Lyophilized

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General info

Function

BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).

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Product protocols

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Target data

BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).
See full target information VWC2
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Product promise

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