Recombinant Human BTF3L4 protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The BTF3L4 protein or Basic Transcription Factor 3-Like 4 is a member of the BTF3 family in humans. It has an approximate molecular weight of 21 kDa and plays a role in transcription regulation. The protein is expressed in various tissues with high levels observed in the testis. Its function is significant in transcription regulation as it acts as a component of the transcription initiation factor complex.

Biological function summary

In the context of transcription regulation BTF3L4 aids in the initiation process by forming a stable complex with RNA polymerase II. This involvement ensures the correct assembly of the transcription machinery at the gene promoter regions. As part of the core transcription factor machinery BTF3L4 interacts with other transcription factors to facilitate gene expression. Its presence is necessary for regulating numerous genes influencing cellular processes such as growth and differentiation.

Pathways

BTF3L4 functions within the transcriptional regulation pathway which is vital for proper gene expression. It has connections with the p53 signaling pathway due to its interaction with other transcription factors influencing cell cycle control. BTF3L4 works alongside proteins like RNA polymerase II and TFIID indicating its role in managing transcriptional fidelity and response to cellular stress signals.

BTF3L4 shows associations with certain cancers including testicular cancer highlighting its role in cellular proliferation and differentiation processes. It connects to the p53 protein in malignancy contexts showing potential implications in tumor suppression mechanisms. Abnormal expression or mutations in BTF3L4 can result in disrupted transcription regulation contributing to oncogenic processes and progression.