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AB271422

Recombinant Human BTN3A1 protein (Tagged)

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Recombinant Human BTN3A1 protein (Tagged) is a Human Fragment protein, in the 31 to 254 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE, WB.

View Alternative Names

CD277, BTF5, BTN3A1, Butyrophilin subfamily 3 member A1

1 Images
SDS-PAGE - Recombinant Human BTN3A1 protein (Tagged) (AB271422)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human BTN3A1 protein (Tagged) (AB271422)

SDS-PAGE analysis of ab271422.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Avi tag C-Terminus Fc tag C-Terminus

Applications

SDS-PAGE, WB

applications

Biologically active

No

Accession

O00481

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"FSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELKWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSDLHVDVKGYKDGGIHLECRSTGWYPQPQIQWSNNKGENIPTVEAPVVADGVGLYAVAASVIMRGSSGEGVSCTIRSSLLGLEKTASISIADPFFRSAQRWIAALAG","proteinLength":"Fragment","predictedMolecularWeight":"53 kDa","actualMolecularWeight":null,"aminoAcidEnd":254,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O00481","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BTN3A1 also known as CD277 is an immunoregulatory protein with a mass of approximately 57 kDa. It belongs to the butyrophilin family part of the immunoglobulin superfamily. BTN3A1 is expressed in a variety of tissues including the immune system where it is present on the surface of immune cells such as T cells and natural killer cells. The protein plays a role in the immune cell activation and modulation.
Biological function summary

BTN3A1 functions as a co-stimulatory molecule in immune responses. It forms part of a receptor complex that modulates T cell activation and cytokine production. BTN3A1 is essential for the recognition and response to phosphoantigens which are small phosphorylated metabolites. This function allows BTN3A1 to regulate immune responses effectively and shape the body's defense against infections.

Pathways

BTN3A1 plays a critical role in the regulation of the γδ T cell activation pathway which is important for immune responses against a variety of pathogens. BTN3A1 interacts with other proteins such as BTN3A2 and B7-H3 facilitating the activation and function of γδ T cells. These interactions influence the immune system's ability to respond appropriately to infections or malignancies.

BTN3A1 has been implicated in autoimmune diseases and cancer. Alterations in BTN3A1 expression or function can contribute to autoimmune disorders due to dysregulated immune responses. Additionally BTN3A1 is studied in the context of cancer where its interactions with proteins like BTN3A3 may influence tumor immune escape mechanisms. Understanding BTN3A1's role in these conditions provides insights into potential therapeutic targets for managing autoimmune diseases and cancer.
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Specifications

Form

Liquid

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General info

Function

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
See full target information BTN3A1
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