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AB271394

Recombinant Human BTNL8 protein (Tagged)

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Recombinant Human BTNL8 protein (Tagged) is a Human Fragment protein, in the 18 to 238 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.

View Alternative Names

UNQ702/PRO1347, BTNL8, Butyrophilin-like protein 8

1 Images
SDS-PAGE - Recombinant Human BTNL8 protein (Tagged) (AB271394)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human BTNL8 protein (Tagged) (AB271394)

SDS-PAGE analysis of 4 μg ab271394.

Key facts

Purity

>90% SDS-PAGE

Expression system

HEK 293 cells

Tags

Avi tag C-Terminus Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6UX41

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>This protein runs at a higher MW by SDS-PAGE due to glycosylation.</p>" } } }
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Sequence info

[{"sequence":"QWQVFGPDKPVQALVGEDAAFSCFLSPKTNAEAMEVRFFRGQFSSVVHLYRDGKDQPFMQMPQYQGRTKLVKDSIAEGRISLRLENITVLDAGLYGCRISSQSYYQKAIWELQVSALGSVPLISITGYVDRDIQLLCQSSGWFPRPTAKWKGPQGQDLSTDSRTNRDMHGLFDVEISLTVQENAGSISCSMRHAHLSREVESRVQIGDTFFEPISWHLATK","proteinLength":"Fragment","predictedMolecularWeight":"54 kDa","actualMolecularWeight":null,"aminoAcidEnd":238,"aminoAcidStart":18,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6UX41","tags":[{"tag":"Avi","terminus":"C-Terminus"},{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BTNL8 also known as butyrophilin-like 8 is a protein involved in immune regulation. It belongs to the butyrophilin (BTN) and butyrophilin-like (BTNL) family of proteins. BTNL8 has an approximate molecular mass of 80 kDa. It is expressed in a variety of tissues but is most abundantly found in epithelial cells. The protein structure suggests roles in cell-to-cell communication and immune response modulation.
Biological function summary

BTNL8 influences the immune system by modulating T-cell activity. It functions as part of the immunological synapse forming complexes that interact with T cells. This interaction can stimulate or inhibit T-cell responses which is significant for maintaining immune homeostasis and preventing overactive immune reactions. BTNL8 is thought to contribute to the balance between pro-inflammatory and regulatory mechanisms within the immune system.

Pathways

BTNL8 plays a role in immune signaling pathways. It is involved in the modulation of the immune checkpoint pathways including the B7-CD28 family of costimulatory and inhibitory molecules. Through these pathways BTNL8 interacts with key proteins such as PD-1 and CTLA-4 which are essential for regulating immune tolerance and activation. These interactions are pivotal for immune surveillance and tolerance mechanisms.

BTNL8 has shown potential connections to autoimmune disorders and cancer. In autoimmune conditions the altered expression or function of BTNL8 may disrupt immune tolerance leading to improper immune attacks on self-tissues. In cancer BTNL8 may participate in immune evasion mechanisms where tumor cells exploit its regulatory functions. Its relationship with other checkpoint proteins like PD-1 can influence the progression and treatment response of tumors providing potential pathways for therapeutic intervention.
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Specifications

Form

Liquid

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General info

Function

May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.

Sequence similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

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Product protocols

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Target data

May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
See full target information BTNL8
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