Recombinant Human BUD31 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

BUD31 also known as Bud Site Selection Protein 31 is a component of the spliceosome machinery and plays an important role in RNA splicing. It weighs about 28 kilodaltons. This protein is expressed in various tissues including the brain and the heart. BUD31 is necessary for proper spliceosome assembly and facilitates mRNA processing by aiding in the removal of introns during pre-mRNA splicing.

Biological function summary

BUD31 interacts with multiple proteins as part of the spliceosomal complex particularly during the catalytic steps of splicing. This interaction is essential for maintaining the fidelity of the splicing process preventing errors that could result in defective or dysfunctional mRNA transcripts. Researchers have observed BUD31 involvement in cellular processes such as cell division and proliferation indicating its importance in cell cycle regulation.

Pathways

Multiple researchers have linked BUD31 to the RNA splicing pathway which is an important step in gene expression. BUD31 also interacts with other spliceosome-associated proteins like SF3B1 highlighting its role in spliceosome assembly and function. Another important pathway is the regulation of the cell cycle where BUD31's influence on mRNA processing affects the expression of genes essential for cell cycle progression. This interaction may influence how cells respond to signals that promote growth or initiate division.

Scientists have linked mutations or dysregulation of BUD31 to cancer. Research suggests that BUD31 impacts the splicing of mRNAs that encode for oncogenes and tumor suppressor genes potentially affecting tumorigenesis. Additionally changes in BUD31 expression could relate to neurodegenerative conditions due to its significant expression in the brain and role in proper mRNA processing. Connections with proteins like BRCA1 in the context of cancer suggest BUD31's influence on cell cycle checkpoints and DNA repair mechanisms.