Recombinant human C10orf99 protein (Active) is a Human Full Length protein, in the 25 to 81 aa range, expressed in Escherichia coli, with >=98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
K R R P A K A W S G R R T R L C C H R V P S P N S T N L K G H H V R L C K P C K L E P E P R L W V V P G A L P Q V
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).
C10orf99, GPR15L, UNQ1833/PRO3446, GPR15LG, Protein GPR15LG, Antimicrobial peptide with 57 amino acid residues, Colon-derived SUSD2 binding factor, Protein GPR15 ligand, Protein GPR15L, Secreted protein C10orf99, AP-57, Antimicrobial peptide-57, CSBF
Recombinant human C10orf99 protein (Active) is a Human Full Length protein, in the 25 to 81 aa range, expressed in Escherichia coli, with >=98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588).
This product is an active protein and may elicit a biological response in vivo, handle with caution.
C10orf99 also recognized as Apal is a small peptide with a molecular weight of approximately 10 kDa. It exhibits expression in several tissues with high levels in the skin and certain epithelial regions. This protein plays a role in innate immunity where it acts as an antimicrobial peptide. Researchers have identified its presence as particularly relevant in the context of skin infections and inflammation suggesting its potential importance in barrier function.
The action of C10orf99 involves modulating the immune response by influencing the activation of immune cells. It does not form part of a complex but interacts directly with cell surface receptors to modify cellular responses. This modulation is vital for maintaining immune homeostasis and combating pathogens as well as managing inflammation in tissue-specific contexts.
C10orf99 engages in immune-related pathways involving innate immunity and epidermal defense. It interacts with proteins such as the interleukin family contributing to the signaling cascades that govern inflammation and immune cell recruitment. The protein's role within the Toll-like receptor (TLR) pathway highlights its importance in recognizing pathogen-associated molecular patterns aiding in initiating appropriate immune responses.
C10orf99 links to conditions like psoriasis and atopic dermatitis disorders often characterized by dysregulated immune activity and inflammation. In these contexts proteins such as IL-17 have been noted for their roles with C10orf99 potentially influencing or mediating their effects. Its antimicrobial properties and role in modulating inflammation highlight its potential as a therapeutic target in managing these skin-related disorders.
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