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AB139611

Recombinant Human C11orf79 protein

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Recombinant Human C11orf79 protein is a Human Full Length protein, in the 30 to 166 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C11orf79, PGL2, SDH5, SDHAF2, SDH assembly factor 2

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SDS-PAGE - Recombinant Human C11orf79 protein (AB139611)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human C11orf79 protein (AB139611)

15% SDS-PAGE analysis of ab139611 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9NX18

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMALLRDFAKNKNKEQRLRAPDLEYLFEKPR","proteinLength":"Full Length","predictedMolecularWeight":"19 kDa","actualMolecularWeight":null,"aminoAcidEnd":166,"aminoAcidStart":30,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NX18","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C11orf79 also known as HAPSTR1 is a protein coding gene. It has a molecular mass of approximately 19 kDa. Researchers have detected its expression in various tissues including the bone marrow spleen and thymus suggesting its physiological role in immune-related contexts. C11orf79 acts mechanistically in cellular contexts where it may influence protein synthesis or transport although detailed mechanical functions remain under investigation.
Biological function summary

C11orf79 impacts cellular processes in the immune system and has links to the HAPSTR complex where it interacts with other proteins to regulate hematopoiesis. The protein contributes to maintaining normal cell function by aiding in the regulation of proliferation and differentiation of myeloid and lymphoid cells. This suggests its involvement in general immune response and hematopoietic homeostasis.

Pathways

C11orf79 participates in pathways related to immune cell development and function. Notably it engages in the Notch signaling pathway which influences hematopoietic cell differentiation and lymphocyte development. Additionally it interacts with proteins such as NOTCH1 and RBPJ which are essential in both the regulation of developmental processes and maintaining cellular identity.

C11orf79 has associations with immune-related diseases like autoimmune lymphoproliferative syndrome (ALPS) and certain leukemias. Its dysfunction may disrupt normal immune cell regulation exacerbating these conditions. Additionally this gene has interactions with proteins like FAS and BAG5 which can influence cell apoptosis and survival suggesting a role in disease pathogenesis where apoptotic pathways become impaired.
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Specifications

Form

Liquid

Additional notes

ab139611 is purified using conventional chromatography techniques.

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General info

Function

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

Sequence similarities

Belongs to the SDHAF2 family.

Subcellular localisation

Mitochondrion matrix

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Product protocols

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Target data

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
See full target information SDHAF2
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Complementary Products

Primary Antibodies

AB14715

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KO Validated

Western blot - Anti-SDHA antibody [2E3GC12FB2AE2] (AB14715)

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Reagents, Controls & Accessories

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Primary Antibodies

AB14714

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Immunocytochemistry/ Immunofluorescence - Anti-SDHB antibody [21A11AE7] (AB14714)

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Reagents, Controls & Accessories

AB110413

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Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

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