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AB168089

Recombinant Human C17orf81 protein (His tag N-Terminus)

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Recombinant Human C17orf81 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C17orf81, DERP6, HSPC002, MSTP071, ELP5, Elongator complex protein 5, Dermal papilla-derived protein 6, S-phase 2 protein

1 Images
SDS-PAGE - Recombinant Human C17orf81 protein (His tag N-Terminus) (AB168089)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human C17orf81 protein (His tag N-Terminus) (AB168089)

15% SDS-PAGE analysis of ab168089 (3 µg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q8TE02

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMTPSEGARAGTGRELEMLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI","proteinLength":"Full Length","predictedMolecularWeight":"37.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":316,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8TE02","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C17orf81 also known as chromosome 17 open reading frame 81 is a protein that functions at the cellular level although its exact mechanical role is still under investigation. The protein has a molecular weight of approximately 30 kDa. Expression of C17orf81 occurs in various human tissues suggesting it may have roles in multiple cellular contexts. Researchers have observed its presence in tissues like the brain and liver indicating its potential significance in these organs.
Biological function summary

C17orf81 adds significance to cellular processes by participating in complex mechanisms that are not yet fully defined. This protein as evidence suggests might interact with other proteins to support cellular functions but its exact biological role requires more study. Current research focuses on understanding these interactions better to clarify the complex pathways C17orf81 influences.

Pathways

Several research studies indicate C17orf81's involvement in cellular signaling and metabolic pathways like the PI3K-Akt pathway. This pathway is important in regulating various cellular activities including cell growth and survival. C17orf81 may also interact with other proteins such as Akt an important signaling protein in this pathway which suggests cooperation in cellular functions. This connection points towards an importance in maintaining cellular balance and responding to external stimuli.

C17orf81's interactions may link it to certain cancers and neurodegenerative diseases. Its potential association with disorders such as glioblastoma highlights its influence in disease progression. In the context of neurodegenerative diseases C17orf81 relates to proteins like tau which are involved in such disorders. Understanding these connections better can aid in identifying therapeutic targets for these conditions.
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Specifications

Form

Liquid

Additional notes

ab168089 was purified using conventional chromatography techniques.

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General info

Function

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed : 29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed : 29332244). Involved in cell migration (By similarity).

Sequence similarities

Belongs to the ELP5 family.

Post-translational modifications

Tyrosine-phosphorylated.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed : 29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed : 29332244). Involved in cell migration (By similarity).
See full target information ELP5
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