Recombinant Human C17orf81 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, MS.
>80% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
M G S S H H H H H H S S G L V P R G S H M G S M T P S E G A R A G T G R E L E M L D S L L A L G G L V L L R D S V E W E G R S L L K A L V K K S A L C G E Q V H I L G C E V S E E E F R E G F D S D I N N R L V Y H D F F R D P L N W S K T E E A F P G G P L G A L R A M C K R T D P V P V T I A L D S L S W L L L R L P C T T L C Q V L H A V S H Q D S C P G D S S S V G K V S V L G L L H E E L H G P G P V G A L S S L A Q T E V T L G G T M G Q A S A H I L C R R P R Q R P T D Q T Q W F S I L P D F S L D L Q E G P S V E S Q P Y S D P H I P P V D P T T H L T F N L H L S K K E R E A R D S L I L P F Q F S S E K Q Q A L L R P R P G Q A T S H I F Y E P D A Y D D L D Q E D P D D D L D I
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity).
C17orf81, DERP6, HSPC002, MSTP071, MSTP071, C17orf81, DERP6, HSPC002, ELP5, Elongator complex protein 5, Dermal papilla-derived protein 6, S-phase 2 protein
Recombinant Human C17orf81 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE, MS.
>80% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
M G S S H H H H H H S S G L V P R G S H M G S M T P S E G A R A G T G R E L E M L D S L L A L G G L V L L R D S V E W E G R S L L K A L V K K S A L C G E Q V H I L G C E V S E E E F R E G F D S D I N N R L V Y H D F F R D P L N W S K T E E A F P G G P L G A L R A M C K R T D P V P V T I A L D S L S W L L L R L P C T T L C Q V L H A V S H Q D S C P G D S S S V G K V S V L G L L H E E L H G P G P V G A L S S L A Q T E V T L G G T M G Q A S A H I L C R R P R Q R P T D Q T Q W F S I L P D F S L D L Q E G P S V E S Q P Y S D P H I P P V D P T T H L T F N L H L S K K E R E A R D S L I L P F Q F S S E K Q Q A L L R P R P G Q A T S H I F Y E P D A Y D D L D Q E D P D D D L D I
Full Length
37.2 kDa
1 to 316
Recombinant
His tag N-Terminus
Liquid
ab168089 was purified using conventional chromatography techniques.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity).
Belongs to the ELP5 family.
Tyrosine-phosphorylated.
Nucleus
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
C17orf81 also known as chromosome 17 open reading frame 81 is a protein that functions at the cellular level although its exact mechanical role is still under investigation. The protein has a molecular weight of approximately 30 kDa. Expression of C17orf81 occurs in various human tissues suggesting it may have roles in multiple cellular contexts. Researchers have observed its presence in tissues like the brain and liver indicating its potential significance in these organs.
C17orf81 adds significance to cellular processes by participating in complex mechanisms that are not yet fully defined. This protein as evidence suggests might interact with other proteins to support cellular functions but its exact biological role requires more study. Current research focuses on understanding these interactions better to clarify the complex pathways C17orf81 influences.
Several research studies indicate C17orf81's involvement in cellular signaling and metabolic pathways like the PI3K-Akt pathway. This pathway is important in regulating various cellular activities including cell growth and survival. C17orf81 may also interact with other proteins such as Akt an important signaling protein in this pathway which suggests cooperation in cellular functions. This connection points towards an importance in maintaining cellular balance and responding to external stimuli.
C17orf81's interactions may link it to certain cancers and neurodegenerative diseases. Its potential association with disorders such as glioblastoma highlights its influence in disease progression. In the context of neurodegenerative diseases C17orf81 relates to proteins like tau which are involved in such disorders. Understanding these connections better can aid in identifying therapeutic targets for these conditions.
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15% SDS-PAGE analysis of ab168089 (3 µg).
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