Recombinant Human C1QC protein (GST tag N-Terminus)
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Recombinant Human C1QC protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 245 aa range, expressed in Wheat germ, with >80%, suitable for ELISA, WB.
View Alternative Names
C1QG, C1QC, Complement C1q subcomponent subunit C
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human C1QC protein (GST tag N-Terminus) (AB157984)
ab157984 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
C1QC is important for recognizing pathogens and apoptotic cells. C1QC is a part of the larger C1 complex essential for immune response effectiveness. By binding to surface molecules on pathogens C1QC triggers a cascade of events that promote cell lysis or phagocytosis. This protein by facilitating immune complex clearance also helps maintain tissue homeostasis and contributes to protection against infections.
Pathways
C1QC plays important roles in the classical complement pathway. Once C1QC identifies a target it activates C1r and C1s initiating a series of proteolytic interactions that result in the formation of the membrane attack complex. Additionally C1QC interacts with proteins like mannose-binding lectin in related pathways linking innate immunity components and further enhancing the body's defense mechanisms.
Specifications
Form
Liquid
Additional notes
Glutathione Sepharose
General info
Function
Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed : 12847249, PubMed : 19006321, PubMed : 24626930, PubMed : 29449492, PubMed : 3258649, PubMed : 34155115, PubMed : 6249812, PubMed : 6776418). The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens : C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain (PubMed : 12847249, PubMed : 19006321, PubMed : 24626930, PubMed : 29449492, PubMed : 3258649, PubMed : 6776418). Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system (PubMed : 29449492). The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed : 19706439, PubMed : 24626930, PubMed : 29449492). The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system (PubMed : 18250442).
Post-translational modifications
O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups.
Target data
Product promise
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