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AB161187

Recombinant Human C1QL1 protein

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Recombinant Human C1QL1 protein is a Human Full Length protein, in the 1 to 258 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C1QRF, CRF, CTRP14, C1QL1, C1q-related factor, C1q and tumor necrosis factor-related protein 14, Complement component 1 Q subcomponent-like 1, C1q/TNF-related protein 14

1 Images
SDS-PAGE - Recombinant Human C1QL1 protein (AB161187)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human C1QL1 protein (AB161187)

ab161187 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O75973

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLLVLVVLIPVLVSSGGPEGHYEMLGTCRMVCDPYPARGPGAGARTDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEPGKPGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYDAASGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASNSVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":258,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75973","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C1QL1 also known as complement C1q-like protein 1 is a member of the C1q protein family. It has an approximate mass of 26 kDa. This protein is primarily expressed in the brain most notably in the cerebellum indicating its role in central nervous system processes. Researchers often investigate C1QL1 because of its structural similarities to complement components despite its distinct function within the neurological context.
Biological function summary

C1QL1 participates in synapse regulation and the maintenance of synaptic plasticity. It forms a part of a larger complex involving several other C1q-like proteins. These complexes contribute to the modulation of synapse formation and pruning by interacting with receptors on post-synaptic neurons. C1QL1's ability to influence synaptic connectivity makes it an important factor in cognitive development and neuroplasticity aspects fundamental to neuronal network adaptations.

Pathways

C1QL1 engages in pathways related to neural development and synaptic signaling. One significant pathway includes the complement cascade where its role diverges from traditional immune functions to support neural development. C1QL1 associates with proteins such as BAFF and APRIL through this pathway. It also plays a part in modulating the Wnt signaling pathway contributing to neuronal positioning and circuitry refinement.

C1QL1 has links to neurological conditions such as autism spectrum disorders and schizophrenia. Its role in synapse formation and plasticity makes it a significant factor in these disorders both characterized by altered synaptic connectivity. Connections to proteins such as NLGN1 and SHANK3 show how alterations in C1QL1 expression or function may lead to disruptions in synaptic balance highlighting its importance in maintaining normal cognitive function.
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Specifications

Form

Liquid

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General info

Function

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

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Product protocols

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Target data

May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
See full target information C1QL1
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Product promise

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