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AB139236

Recombinant Human C2orf60 protein

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Recombinant Human C2orf60 protein is a Human Full Length protein, in the 1 to 315 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C2orf60, TYW5, tRNA wybutosine-synthesizing protein 5, hTYW5, tRNA yW-synthesizing protein 5, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase

1 Images
SDS-PAGE - Recombinant Human C2orf60 protein (AB139236)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human C2orf60 protein (AB139236)

15% SDS-PAGE analysis of 3 µg ab139236.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

A2RUC4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE","proteinLength":"Full Length","predictedMolecularWeight":"38.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":315,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"A2RUC4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C2orf60 also known as Chromosome 2 Open Reading Frame 60 is a protein encoded by the C2orf60 gene. This protein does not have a known specific mass at this time due to its obscure nature. Expression of C2orf60 can be detected in various tissues with higher expressions noted in specific regions of the brain suggesting a potential role in central nervous system functions.
Biological function summary

C2orf60 is thought to be involved in modulating cellular processes such as cell signaling and communication. Though current data is limited studies indicate potential participation in methylation pathways or chromatin remodeling. Researchers speculate its involvement in complex protein interactions rather than acting as a solitary actor suggesting that it might form part of a larger protein assembly that regulates gene expression.

Pathways

The potential involvement of C2orf60 in pathways suggests a function in epigenetic regulation. Preliminary data hints at its participation in pathways associated with chromatin structure modification. In these pathways it could interact with proteins like DNA methyltransferases or histone modifiers. Such connections hint at C2orf60 playing a part in transcriptional regulation impacting gene expression patterns in specific tissues.

Researchers have associated the C2orf60 protein with neurological disorders and certain cancers. Studies indicate possible links to disorders such as schizophrenia with potential connections to proteins like DISC1. Furthermore preliminary evidence suggests a role in tumor growth implicating interactions with oncogene-related pathways. Continued research aims to clarify these associations and understand the protein's exact involvement in these conditions.
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Specifications

Form

Liquid

Additional notes

ab139236 is purified using conventional chromatography techniques.

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General info

Function

tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.

Sequence similarities

Belongs to the TYW5 family.

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Product protocols

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Target data

tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
See full target information TYW5
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