Recombinant Human CAB3 protein is a Human Full Length protein, in the 1 to 484 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M Y D D S Y V P G F E D S E A G S A D S Y T S R P S L D S D V S L E E D R E S A R R E V E S Q A Q Q Q L E R A K H K P V A F A V R T N V S Y C G V L D E E C P V Q G S G V N F E A K D F L H I K E K Y S N D W W I G R L V K E G G D I A F I P S P Q R L E S I R L K Q E Q K A R R S G N P S S L S D I G N R R S P P P S L A K Q K Q K Q A E H V P P Y D V V P S M R P V V L V G P S L K G Y E V T D M M Q K A L F D F L K H R F D G R I S I T R V T A D L S L A K R S V L N N P G K R T I I E R S S A R S S I A E V Q S E I E R I F E L A K S L Q L V V L D A D T I N H P A Q L A K T S L A P I I V F V K V S S P K V L Q R L I R S R G K S Q M K H L T V Q M M A Y D K L V Q C P P E S F D V I L D E N Q L E D A C E H L A E Y L E V Y W R A T H H P A P G P G L L G P P S A I P G L Q N Q Q L L G E R G E E H S P L E R D S L M P S D E A S E S S R Q A W T G S S Q R S S R H L E E D Y A D A Y Q D L Y Q P H R Q H T S G L P S A N G H D P Q D R L L A Q D S E H N H S D R N W Q R N R P W P K D S Y
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Alternative names
CACNLB3, CACNB3, Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3
Recommended products
Recombinant Human CAB3 protein is a Human Full Length protein, in the 1 to 484 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P54284-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M Y D D S Y V P G F E D S E A G S A D S Y T S R P S L D S D V S L E E D R E S A R R E V E S Q A Q Q Q L E R A K H K P V A F A V R T N V S Y C G V L D E E C P V Q G S G V N F E A K D F L H I K E K Y S N D W W I G R L V K E G G D I A F I P S P Q R L E S I R L K Q E Q K A R R S G N P S S L S D I G N R R S P P P S L A K Q K Q K Q A E H V P P Y D V V P S M R P V V L V G P S L K G Y E V T D M M Q K A L F D F L K H R F D G R I S I T R V T A D L S L A K R S V L N N P G K R T I I E R S S A R S S I A E V Q S E I E R I F E L A K S L Q L V V L D A D T I N H P A Q L A K T S L A P I I V F V K V S S P K V L Q R L I R S R G K S Q M K H L T V Q M M A Y D K L V Q C P P E S F D V I L D E N Q L E D A C E H L A E Y L E V Y W R A T H H P A P G P G L L G P P S A I P G L Q N Q Q L L G E R G E E H S P L E R D S L M P S D E A S E S S R Q A W T G S S Q R S S R H L E E D Y A D A Y Q D L Y Q P H R Q H T S G L P S A N G H D P Q D R L L A Q D S E H N H S D R N W Q R N R P W P K D S Y
- Accession
- P54284
- Protein length
- Full Length
- Predicted molecular weight
- 80.9 kDa
- Amino acids
- 1 to 484
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
- Sequence similarities
Belongs to the calcium channel beta subunit family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as CACNB3.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CAB3 also known as calcineurin B homologous protein 3 (CaCNB3) is a protein involved in intracellular signaling. The protein weighs approximately 22 kDa and expresses in various tissues including the heart and brain. Functionally CAB3 participates in calcium-binding and signaling processes facilitating interactions essential for cellular responses to changes in calcium levels.
- Biological function summary
CAB3 plays an integral role in calcium-dependent signaling pathways. This protein functions as part of a larger calcineurin complex alongside calcineurin A. CAB3 and the complex it forms modulate the activity of several downstream targets influencing cellular processes like gene expression and cytoskeletal dynamics. In neurons CAB3 contributes to the synaptic plasticity necessary for learning and memory.
- Pathways
CAB3 is an important component in calcium and NFAT signaling pathways. It directly regulates these pathways impacting gene expression and cellular development. CAB3 interacts with other proteins like calmodulin which facilitates its binding and functional actions within the pathway. Through modulation of these pathways CAB3 participates in orchestrating cellular responses to external stimuli.
- Associated diseases and disorders
Mutations or dysregulation of CAB3 relate to cardiac hypertrophy and neurodegenerative diseases such as Alzheimer’s. Misregulation of CAB3 activity can disrupt calcium homeostasis aggravating disease processes. The connection to calcineurin is significant as alterations in this relationship could influence the progression of these disorders offering potential targets for therapeutic intervention.
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1 product image
SDS-PAGE - Recombinant Human CAB3 protein (ab132175)
12.5% SDS-PAGE analysis of ab132175 stained with Coomassie Blue.
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