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AB132175

Recombinant Human CAB3 protein (GST tag N-Terminus)

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Recombinant Human CAB3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 484 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

CACNLB3, CACNB3, Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3

1 Images
SDS-PAGE - Recombinant Human CAB3 protein (GST tag N-Terminus) (AB132175)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CAB3 protein (GST tag N-Terminus) (AB132175)

12.5% SDS-PAGE analysis of ab132175 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

P54284

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Cell Lines & Lysates

AB265180

Human CACNB3 (CAB3) knockout HeLa cell line

Sanger Sequencing - Human CACNB3 (CAB3) knockout HeLa cell line (AB265180)

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Cell Lines & Lysates

AB263132

Human CACNB3 (CAB3) knockout HeLa cell lysate

Sanger Sequencing - Human CACNB3 (CAB3) knockout HeLa cell lysate (AB263132)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as CACNB3.
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Sequence info

[{"sequence":"MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY","proteinLength":"Full Length","predictedMolecularWeight":"80.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":484,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P54284","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAB3 also known as calcineurin B homologous protein 3 (CaCNB3) is a protein involved in intracellular signaling. The protein weighs approximately 22 kDa and expresses in various tissues including the heart and brain. Functionally CAB3 participates in calcium-binding and signaling processes facilitating interactions essential for cellular responses to changes in calcium levels.
Biological function summary

CAB3 plays an integral role in calcium-dependent signaling pathways. This protein functions as part of a larger calcineurin complex alongside calcineurin A. CAB3 and the complex it forms modulate the activity of several downstream targets influencing cellular processes like gene expression and cytoskeletal dynamics. In neurons CAB3 contributes to the synaptic plasticity necessary for learning and memory.

Pathways

CAB3 is an important component in calcium and NFAT signaling pathways. It directly regulates these pathways impacting gene expression and cellular development. CAB3 interacts with other proteins like calmodulin which facilitates its binding and functional actions within the pathway. Through modulation of these pathways CAB3 participates in orchestrating cellular responses to external stimuli.

Mutations or dysregulation of CAB3 relate to cardiac hypertrophy and neurodegenerative diseases such as Alzheimer’s. Misregulation of CAB3 activity can disrupt calcium homeostasis aggravating disease processes. The connection to calcineurin is significant as alterations in this relationship could influence the progression of these disorders offering potential targets for therapeutic intervention.
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Specifications

Form

Liquid

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General info

Function

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed : 8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).

Sequence similarities

Belongs to the calcium channel beta subunit family.

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Product protocols

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Target data

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed : 8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
See full target information CACNB3
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