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AB98230

Recombinant Human CAB39/MO25 protein

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Recombinant Human CAB39/MO25 protein is a Human Full Length protein, in the 1 to 341 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MO25, CGI-66, CAB39, Calcium-binding protein 39, MO25alpha, Protein Mo25

1 Images
SDS-PAGE - Recombinant Human CAB39/MO25 protein (AB98230)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CAB39/MO25 protein (AB98230)

15% SDS-PAGE analysis of 3μg ab98230

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9Y376

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as CAB39.
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVSKNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIFNNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKIILWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLKRPAQQEA","proteinLength":"Full Length","predictedMolecularWeight":"42 kDa","actualMolecularWeight":null,"aminoAcidEnd":341,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y376","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CAB39 also known as MO25 is a protein that plays an important role in cellular signaling. It has a mass of about 40 kDa and is predominantly expressed in the cytoplasm. CAB39 is part of the STE20-related kinase adaptor (STRAD) complex and functions to stabilize the scaffolding necessary for various kinase interactions. This protein is a subunit of the LKB1 complex essential for kinase activity. It modulates activity by binding to other proteins like STRAD and LKB1 enhancing their stability and function.
Biological function summary

CAB39 influences several cellular processes by acting as a scaffolding protein. It is an integral component of the LKB1-STRAD-MO25 complex essential for proper kinase activity. This complex regulates AMPK signaling pathways which are important for cellular energy homeostasis and metabolism. CAB39 by interacting with these kinases regulates energy balance within cells particularly muscle and liver tissues. This regulation influences cell polarity and growth impacting cell survival and division.

Pathways

CAB39 is significant in both the AMPK and mTOR signaling pathways playing a role in energy sensing and cellular growth regulation. In these pathways CAB39 modulates the activity of proteins like AMPK and LKB1. The AMPK pathway is important for maintaining energy homeostasis and is activated under low energy conditions while the mTOR pathway relates to cell growth and autophagy. CAB39’s role in these pathways highlights its importance in controlling metabolic responses to nutrient availability and stress.

CAB39 has implications in cancer and metabolic syndromes. Alterations in its function can disrupt normal AMPK and mTOR signaling leading to unchecked cell proliferation observed in cancer particularly in Peutz-Jeghers syndrome where LKB1 mutations are common. Additionally defects in CAB39-related pathways can lead to metabolic disorders like type 2 diabetes. By regulating AMPK activity CAB39 interacts indirectly with proteins such as PRKAA1 and PRKAA2 influencing insulin sensitivity and glucose metabolism.
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Specifications

Form

Liquid

Additional notes

ab98230 was purified using conventional chromatography techniques.

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General info

Function

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.

Sequence similarities

Belongs to the Mo25 family.

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Product protocols

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Target data

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
See full target information CAB39
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