Recombinant Human CAB39/MO25 protein is a Human Full Length protein, in the 1 to 341 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M P F P F G K S H K S P A D I V K N L K E S M A V L E K Q D I S D K K A E K A T E E V S K N L V A M K E I L Y G T N E K E P Q T E A V A Q L A Q E L Y N S G L L S T L V A D L Q L I D F E G K K D V A Q I F N N I L R R Q I G T R T P T V E Y I C T Q Q N I L F M L L K G Y E S P E I A L N C G I M L R E C I R H E P L A K I I L W S E Q F Y D F F R Y V E M S T F D I A S D A F A T F K D L L T R H K L L S A E F L E Q H Y D R F F S E Y E K L L H S E N Y V T K R Q S L K L L G E L L L D R H N F T I M T K Y I S K P E N L K L M M N L L R D K S R N I Q F E A F H V F K V F V A N P N K T Q P I L D I L L K N Q A K L I E F L S K F Q N D R T E D E Q F N D E K T Y L V K Q I R D L K R P A Q Q E A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Alternative names
MO25, CGI-66, CAB39, Calcium-binding protein 39, MO25alpha, Protein Mo25
Recommended products
Recombinant Human CAB39/MO25 protein is a Human Full Length protein, in the 1 to 341 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9Y376-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M P F P F G K S H K S P A D I V K N L K E S M A V L E K Q D I S D K K A E K A T E E V S K N L V A M K E I L Y G T N E K E P Q T E A V A Q L A Q E L Y N S G L L S T L V A D L Q L I D F E G K K D V A Q I F N N I L R R Q I G T R T P T V E Y I C T Q Q N I L F M L L K G Y E S P E I A L N C G I M L R E C I R H E P L A K I I L W S E Q F Y D F F R Y V E M S T F D I A S D A F A T F K D L L T R H K L L S A E F L E Q H Y D R F F S E Y E K L L H S E N Y V T K R Q S L K L L G E L L L D R H N F T I M T K Y I S K P E N L K L M M N L L R D K S R N I Q F E A F H V F K V F V A N P N K T Q P I L D I L L K N Q A K L I E F L S K F Q N D R T E D E Q F N D E K T Y L V K Q I R D L K R P A Q Q E A
- Accession
- Q9Y376
- Protein length
- Full Length
- Predicted molecular weight
- 42 kDa
- Amino acids
- 1 to 341
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab98230 was purified using conventional chromatography techniques.
General info
- Function
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
- Sequence similarities
Belongs to the Mo25 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Previously labelled as CAB39.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CAB39 also known as MO25 is a protein that plays an important role in cellular signaling. It has a mass of about 40 kDa and is predominantly expressed in the cytoplasm. CAB39 is part of the STE20-related kinase adaptor (STRAD) complex and functions to stabilize the scaffolding necessary for various kinase interactions. This protein is a subunit of the LKB1 complex essential for kinase activity. It modulates activity by binding to other proteins like STRAD and LKB1 enhancing their stability and function.
- Biological function summary
CAB39 influences several cellular processes by acting as a scaffolding protein. It is an integral component of the LKB1-STRAD-MO25 complex essential for proper kinase activity. This complex regulates AMPK signaling pathways which are important for cellular energy homeostasis and metabolism. CAB39 by interacting with these kinases regulates energy balance within cells particularly muscle and liver tissues. This regulation influences cell polarity and growth impacting cell survival and division.
- Pathways
CAB39 is significant in both the AMPK and mTOR signaling pathways playing a role in energy sensing and cellular growth regulation. In these pathways CAB39 modulates the activity of proteins like AMPK and LKB1. The AMPK pathway is important for maintaining energy homeostasis and is activated under low energy conditions while the mTOR pathway relates to cell growth and autophagy. CAB39’s role in these pathways highlights its importance in controlling metabolic responses to nutrient availability and stress.
- Associated diseases and disorders
CAB39 has implications in cancer and metabolic syndromes. Alterations in its function can disrupt normal AMPK and mTOR signaling leading to unchecked cell proliferation observed in cancer particularly in Peutz-Jeghers syndrome where LKB1 mutations are common. Additionally defects in CAB39-related pathways can lead to metabolic disorders like type 2 diabetes. By regulating AMPK activity CAB39 interacts indirectly with proteins such as PRKAA1 and PRKAA2 influencing insulin sensitivity and glucose metabolism.
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1 product image
SDS-PAGE - Recombinant Human CAB39/MO25 protein (ab98230)
15% SDS-PAGE analysis of 3μg ab98230
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