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AB95489

Recombinant Human CacyBP protein (His tag N-Terminus)

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Recombinant Human CacyBP protein (His tag N-Terminus) is a Human Fragment protein, in the 1 to 185 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

S100A6BP, SIP, PNAS-107, CACYBP, Calcyclin-binding protein, CacyBP, hCacyBP, S100A6-binding protein, Siah-interacting protein

1 Images
SDS-PAGE - Recombinant Human CacyBP protein (AB95489)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human CacyBP protein (AB95489)

15% SDS-PAGE analysis of ab95489 (3ug)

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9HB71

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as SIAH Interacting Protein
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMQQKSQKKAELLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKVENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":185,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9HB71","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CacyBP also known as Calcyclin Binding Protein is involved in various cellular processes and interactions. This protein has a molecular mass of about 30 kDa. It is broadly expressed in many tissues including the brain where it plays significant roles. CacyBP interacts with several other proteins impacting cellular structures and functions through complex interactions.
Biological function summary

CacyBP regulates key cellular functions by interacting with signaling pathways and cytoskeletal elements. It can form part of multi-protein complexes influencing the stability and structure of cytoskeletal components. CacyBP also modifies proteins by dephosphorylation impacting processes such as cell division and differentiation. These functions underline its involvement in cellular maintenance and dynamic processes.

Pathways

CacyBP participates in cellular signaling and protein degradation pathways. It plays a role in the ubiquitin-proteasome pathway by mediating the degradation of specific substrate proteins. This protein associates with Siah-1 an E3 ubiquitin-protein ligase emphasizing its function in this pathway. CacyBP is also linked to ERK1/2 signaling pathways interacting with proteins like ERK2 to modulate cell proliferation and differentiation.

CacyBP has connections to cancer and neurodegenerative diseases. In cancer CacyBP influences tumor growth and progression by affecting cell cycle regulation and apoptosis. It interacts with proteins such as p53 which play roles in cell cycle control and tumor suppression. In neurodegenerative diseases like Alzheimer's altered CacyBP expression levels have been observed implicating it in the disorder’s pathology through interactions with tau protein.
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Specifications

Form

Liquid

Additional notes

Purified by using conventional chromatography techniques

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General info

Function

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Post-translational modifications

Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
See full target information CACYBP
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Complementary Products

Primary Antibodies

AB249684

Anti-CacyBP antibody [EPR12374] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CacyBP antibody [EPR12374] - BSA and Azide free (AB249684)

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Primary Antibodies

AB16045

Anti-Cyclophilin B antibody - Loading Control

KO Validated|Lab Essentials

Western blot - Anti-Cyclophilin B antibody - Loading Control (AB16045)

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PGLS antibody (AB229872)

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Proteins & Peptides

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