Recombinant Human CacyBP protein is a Human Fragment protein, in the 1 to 185 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M Q Q K S Q K K A E L L D N E K P A A V V A P I T T G Y T V K I S N Y G W D Q S D K F V K I Y I T L T G V H Q V P T E N V Q V H F T E R S F D L L V K N L N G K S Y S M I V N N L L K P I S V E G S S K K V K T D T V L I L C R K K V E N T R W D Y L T Q V E K E C K E K E K P S Y D T E T D P S E G L M N V L K K I Y E D G D D D M K R T I N K A W V E S R E K Q A K G D T E F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Alternative names
S100A6BP, SIP, PNAS-107, CACYBP, Calcyclin-binding protein, CacyBP, hCacyBP, S100A6-binding protein, Siah-interacting protein
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Recombinant Human CacyBP protein is a Human Fragment protein, in the 1 to 185 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9HB71-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M Q Q K S Q K K A E L L D N E K P A A V V A P I T T G Y T V K I S N Y G W D Q S D K F V K I Y I T L T G V H Q V P T E N V Q V H F T E R S F D L L V K N L N G K S Y S M I V N N L L K P I S V E G S S K K V K T D T V L I L C R K K V E N T R W D Y L T Q V E K E C K E K E K P S Y D T E T D P S E G L M N V L K K I Y E D G D D D M K R T I N K A W V E S R E K Q A K G D T E F
- Accession
- Q9HB71
- Protein length
- Fragment
- Amino acids
- 1 to 185
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
Purified by using conventional chromatography techniques
General info
- Function
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
- Post-translational modifications
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as SIAH Interacting Protein
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
CacyBP also known as Calcyclin Binding Protein is involved in various cellular processes and interactions. This protein has a molecular mass of about 30 kDa. It is broadly expressed in many tissues including the brain where it plays significant roles. CacyBP interacts with several other proteins impacting cellular structures and functions through complex interactions.
- Biological function summary
CacyBP regulates key cellular functions by interacting with signaling pathways and cytoskeletal elements. It can form part of multi-protein complexes influencing the stability and structure of cytoskeletal components. CacyBP also modifies proteins by dephosphorylation impacting processes such as cell division and differentiation. These functions underline its involvement in cellular maintenance and dynamic processes.
- Pathways
CacyBP participates in cellular signaling and protein degradation pathways. It plays a role in the ubiquitin-proteasome pathway by mediating the degradation of specific substrate proteins. This protein associates with Siah-1 an E3 ubiquitin-protein ligase emphasizing its function in this pathway. CacyBP is also linked to ERK1/2 signaling pathways interacting with proteins like ERK2 to modulate cell proliferation and differentiation.
- Associated diseases and disorders
CacyBP has connections to cancer and neurodegenerative diseases. In cancer CacyBP influences tumor growth and progression by affecting cell cycle regulation and apoptosis. It interacts with proteins such as p53 which play roles in cell cycle control and tumor suppression. In neurodegenerative diseases like Alzheimer's altered CacyBP expression levels have been observed implicating it in the disorder’s pathology through interactions with tau protein.
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1 product image
SDS-PAGE - Recombinant Human CacyBP protein (ab95489)
15% SDS-PAGE analysis of ab95489 (3ug)
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