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AB276209

Recombinant Human Cadherin 8 protein (His tag)

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Recombinant Human Cadherin 8 protein (His tag) is a Human Fragment protein, in the 1 to 621 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Cadherin-8, CDH8

1 Images
SDS-PAGE - Recombinant Human Cadherin 8 protein (His tag) (AB276209)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Cadherin 8 protein (His tag) (AB276209)

SDS-PAGE analysis of ab276209

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P55286

Animal free

No

Carrier free

Yes

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSM","proteinLength":"Fragment","predictedMolecularWeight":"66.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":621,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P55286","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Cadherin 8 also known as CDH8 is a member of the cadherin superfamily specifically a type II classical cadherin. It has a molecular mass of approximately 125 kDa. This protein functions mechanically by facilitating calcium-dependent cell-cell adhesion which is important in maintaining proper cellular architecture. Cadherin 8 is primarily expressed in the nervous system where it plays a role in the development and maintenance of neural networks.
Biological function summary

Cadherin 8 contributes to the formation and specification of synaptic connections in the developing brain. It participates in homophilic interactions meaning it adheres to other Cadherin 8 molecules on adjacent cells. Although Cadherin 8 does not engage in well-characterized complexes like other members of its family its function is essential for organizing tissue structure. It acts in coordination with other proteins contributing to the intricate design of cellular systems within the brain.

Pathways

The activity of Cadherin 8 integrates into neural development and synaptic organization pathways. It aligns with the Wnt signaling pathway which influences cell fate and synaptic plasticity. Here its interaction with beta-catenin links cadherin-based adhesion to intracellular signaling pathways. The effective coordination with other cadherins such as N-cadherin provides complementary roles in synaptic morphogenesis ensuring the proper connectivity in the developing nervous system.

The functional impairment or dysregulation of Cadherin 8 has been implicated in neurodevelopmental disorders like autism spectrum disorder (ASD). Alterations in the expression or function of Cadherin 8 may disrupt synaptic connections leading to developmental anomalies. Additionally its relationship with proteins such as beta-catenin links it to pathways altered in ASD emphasizing the critical balance and interaction Cadherin 8 holds within neural network formation.
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Specifications

Form

Lyophilized

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General info

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

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Product protocols

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
See full target information CDH8
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