Recombinant Human Calcineurin BII/PPP3R2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calcineurin BII also known as PPP3R2 is a regulatory subunit of the calcineurin heterodimeric complex. Calcineurin BII mainly constitutes the regulatory component of this phosphatase which has a molecular mass of approximately 19 kDa. It is expressed in various tissues with significant presence in the brain and immune cells. Calcineurin BII interacts with the catalytic subunit (calcineurin A) to form the active calcineurin enzyme which is an important player in several intracellular processes.

Biological function summary

Calcineurin BII serves as a calcium sensor that regulates the enzyme's phosphatase activity. The interaction with calcineurin A forms the dimeric complex necessary for its activity. This complex plays an important role in dephosphorylating proteins which is essential for modifying protein function and signaling pathways. Calcineurin BII controls cellular responses like T-cell activation by responding to calcium influxes impacting immune responses and neuronal signaling.

Pathways

Calcineurin BII has important implications in both the calcium signaling pathway and the immune signaling pathway. In the calcium signaling pathway calcineurin BII works alongside the calcineurin A subunit to regulate the dephosphorylation of nuclear factor of activated T-cells (NFAT) a transcription factor. This regulation extends to immune responses as calcineurin BII is instrumental in T-cell receptor signaling where it influences NFAT to modulate gene expression critical for T-cell function.

Calcineurin BII relates to autoimmune diseases and neurodegenerative disorders. In autoimmune diseases abnormal activation of calcineurin BII and its associated pathways can cause excessive immune responses. Meanwhile in neurodegenerative disorders its dysregulation affects neuronal signaling pathways potentially adding to disease pathogenesis. Calcineurin BII further interacts with proteins like NFAT in these disease contexts emphasizing its role in pathological signaling alterations.