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AB137168

Recombinant Human Calcipressin 3 protein (denatured)

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Recombinant Human Calcipressin 3 protein (denatured) is a Human Fragment protein, in the 56 to 241 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

DSCR1L2, RCAN3, Calcipressin-3, Down syndrome candidate region 1-like protein 2, Myocyte-enriched calcineurin-interacting protein 3, Regulator of calcineurin 3, MCIP3

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SDS-PAGE - Recombinant Human Calcipressin 3 protein (denatured) (AB137168)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Calcipressin 3 protein (denatured) (AB137168)

15% SDS-PAGE analysis of ab137168 (3μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UKA8

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 12.01% Urea, 1.17% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEAVFEAREQKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQVQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKIAQTRRPDPPTAALNEPQTFDCAL","proteinLength":"Fragment","predictedMolecularWeight":"23.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":241,"aminoAcidStart":56,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UKA8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calcipressin 3 also known as RCAN3 is a protein with a molecular mass of approximately 25 kDa. This protein is expressed in various tissues including the brain and heart. Mechanically Calcipressin 3 interacts with calcineurin a calcium/calmodulin-dependent serine/threonine phosphatase. Calcipressin 3 serves as an endogenous inhibitor regulating the phosphatase activity of calcineurin which is important for many cellular processes that rely on calcium signaling.
Biological function summary

Calcipressin 3 acts as a modulatory component in calcium signaling influencing immune responses and neuronal development. It is part of a regulatory complex that interacts with calcineurin modulating signal transduction pathways. This interaction plays a role in T-cell activation and differentiation by affecting transcription factors such as NFAT. Calcipressin 3's ability to modulate these pathways highlights its importance in maintaining cellular homeostasis.

Pathways

Calcipressin 3 significantly influences the calcineurin-NFAT signaling pathway which is essential for T-cell activation and various other cellular processes. This pathway impacts immune system function and cardiovascular development. Calcipressin 3 also has connections to the MAPK signaling pathway indicating interactions with proteins like MEK and ERK which are key in transmitting cellular signals. These pathways illustrate how Calcipressin 3 coordinates calcium-mediated responses in the body.

Calcipressin 3 has associations with cardiac hypertrophy and Down syndrome. Patients with Down syndrome often show dysregulation in calcineurin activity partially due to altered levels of Calcipressin 3 and its interaction with proteins like DSCR1. In cardiac hypertrophy cases Calcipressin 3's modulation of calcineurin activity affects heart muscle cell growth and remodeling. Understanding these interactions offers insights into the treatment and management of these conditions.
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Specifications

Form

Liquid

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General info

Function

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).

Sequence similarities

Belongs to the RCAN family.

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Product protocols

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Target data

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
See full target information RCAN3
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