JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB105131

Recombinant Human calcyphosine protein

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human calcyphosine protein is a Human Full Length protein, in the 1 to 189 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Calcyphosin, Calcyphosine, CAPS

1 Images
SDS-PAGE - Recombinant Human calcyphosine protein (AB105131)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human calcyphosine protein (AB105131)

15% SDS-PAGE showing ab105131 (3 μg) at approximately 23.1 kDa.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q13938

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMDAVDATMEKLRAQCLSRGASGIQGLARFFRQLDRDGSRSLDADEFRQGLAKLGLVLDQAEAEGVCRKWDRNGSGTLDLEEFLRALRPPMSQAREAVIAAAFAKLDRSGDGVVTVDDLRGVYSGRAHPKVRSGEWTEDEVLRRFLDNFDSSEKDGQVTLAEFQDYYSGVSASMNTDEEFVAMMTSAWQL","proteinLength":"Full Length","predictedMolecularWeight":"23.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q13938","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calcyphosine also known as CAPS is a calcium-binding protein with a molecular mass of approximately 22 kDa. It plays a role in intracellular calcium signaling. Calcyphosine expression occurs widely in multiple tissues with high levels observed in the thyroid gland and epithelial tissues. It binds calcium ions impacting cellular processes such as signal transduction and cell communication.
Biological function summary

Calcyphosine influences several cellular functions related to calcium homeostasis and signaling. It does not form part of any larger complex but modulates cellular activities by regulating calcium ion concentrations inside cells. This regulation is critical for functions like muscle contraction hormone secretion and neurotransmitter release. Its presence in different tissues suggests diverse roles depending on the cellular environment.

Pathways

Calcyphosine plays a role in calcium-dependent pathways significant for maintaining cellular activities. It intersects with the calcium signaling pathway affecting proteins like calmodulin and calcineurin which further mediate various cellular responses. These interactions alter signal transmission processes vital for cell responses and adaptations.

Studies have noted calcyphosine's involvement in thyroid-related conditions and some cancers. Altered expression levels link the protein to thyroid disorders potentially affecting thyroid hormone production and regulation. Calcyphosine's interaction with proteins like TSH receptor and thyroid transcription factors highlights its role in thyroid function and its potential influence on thyroid pathology and neoplastic conditions.
style
left-column

Specifications

Form

Liquid

Additional notes

ab105131 is purified using conventional chromatography techniques.

style
left-column

General info

Function

Calcium-binding protein. May play a role in cellular signaling events (Potential).

style
left-column

Product protocols

style
left-column

Target data

Calcium-binding protein. May play a role in cellular signaling events (Potential).
See full target information Calcyphosin
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal 40:8976-8993 PubMed33055278

2020

Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea.

Applications

Unspecified application

Species

Unspecified reactive species

Jorge Fernández-Trillo,Danny Florez-Paz,Almudena Íñigo-Portugués,Omar González-González,Ana Gómez Del Campo,Alejandro González,Félix Viana,Carlos Belmonte,Ana Gomis
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB51205

Recombinant human PPM1A protein

Bioactive

SDS-PAGE - Recombinant human PPM1A protein (AB51205)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB41500

Rabbit Anti-Chicken IgY H&L (15nm Gold)

  • 0
  • 0
Secondary Antibodies

AB150121

Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488) (AB150121)

  • 5
  • 5

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com