Recombinant Human Calneuron 1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Calneuron 1 also known as CABP8 is a calcium-binding protein encoded by the CALN1 gene. This protein has a molecular mass of approximately 25 kDa. Calneuron 1 is mainly expressed in the brain particularly in the cerebellum and hippocampus regions. Its main function is to modulate calcium signaling impacting the activity of specific calcium ion channels in neuronal cells. The protein performs an important role in synaptic signaling and plasticity.

Biological function summary

Calneuron 1 affects calcium-dependent processes and it interacts closely with other calcium sensors in neurons. It does not function as part of a larger protein complex but works by binding calcium ions. This action aids in the regulation of intracellular calcium levels and contributes to normal neuronal signaling. The presence of Calneuron 1 ensures a proper cellular response to calcium fluctuations which is necessary for synaptic transmission and other neuronal activities.

Pathways

Calcium signaling pathways include Calneuron 1 as a regulatory protein. In the neuronal calcium sensor pathway Calneuron 1 interacts with other proteins like calmodulin and calcineurin to modulate synaptic functions. Another pathway involving Calneuron 1 is the synaptic plasticity pathway where it influences the balance between excitation and inhibition in neurons contributing to learning and memory processes.

Abnormalities in Calneuron 1 expression have connections to neurodegenerative diseases such as Alzheimer's disease and epilepsy. In Alzheimer's altered calcium regulation impacts amyloid-beta processing where Calneuron 1 interacts with proteins like amyloid precursor protein (APP). In epilepsy changes in calcium signaling can lead to increased neuronal excitability where Calneuron 1 may contribute through interactions affecting ion channel activity. Understanding Calneuron 1's role provides insights into these conditions and potential therapeutic targets.