Recombinant Human Calsequestrin 2 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M R G S H H H H H H G M A S M T G G Q Q M G R D L Y D D D D K D R W G S M E E G L N F P T Y D G K D R V V S L S E K N F K Q V L K K Y D L L C L Y Y H E P V S S D K V T Q K Q F Q L K E I V L E L V A Q V L E H K A I G F V M V D A K K E A K L A K K L G F D E E G S L Y I L K G D R T I E F D G E F A A D V L V E F L L D L I E D P V E I I S S K L E V Q A F E R I E D Y I K L I G F F K S E D S E Y Y K A F E E A A E H F Q P Y I K F F A T F D K G V A K K L S L K M N E V D F Y E P F M D E P I A I P N K P Y T E E E L V E F V K E H Q R P T L R R L R P E E M F E T W E D D L N G I H I V A F A E K S D P D G Y E F L E I L K Q V A R D N T D N P D L S I L W I D P D D F P L L V A Y W E K T F K I D L F R P Q I G V V N V T D A D S V W M E I P D D D D L P T A E E L E D W I E D V L S G K I N T E D D D E D D D D D D N S D E E D N D D S D D D D D E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Alternative names
Calsequestrin-2, CASQ2
Recommended products
Recombinant Human Calsequestrin 2 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- O14958-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M R G S H H H H H H G M A S M T G G Q Q M G R D L Y D D D D K D R W G S M E E G L N F P T Y D G K D R V V S L S E K N F K Q V L K K Y D L L C L Y Y H E P V S S D K V T Q K Q F Q L K E I V L E L V A Q V L E H K A I G F V M V D A K K E A K L A K K L G F D E E G S L Y I L K G D R T I E F D G E F A A D V L V E F L L D L I E D P V E I I S S K L E V Q A F E R I E D Y I K L I G F F K S E D S E Y Y K A F E E A A E H F Q P Y I K F F A T F D K G V A K K L S L K M N E V D F Y E P F M D E P I A I P N K P Y T E E E L V E F V K E H Q R P T L R R L R P E E M F E T W E D D L N G I H I V A F A E K S D P D G Y E F L E I L K Q V A R D N T D N P D L S I L W I D P D D F P L L V A Y W E K T F K I D L F R P Q I G V V N V T D A D S V W M E I P D D D D L P T A E E L E D W I E D V L S G K I N T E D D D E D D D D D D N S D E E D N D D S D D D D D E
- Accession
- O14958
- Protein length
- Full Length
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab93736 was purified using conventional chromatography techniques.
General info
- Function
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
- Sequence similarities
Belongs to the calsequestrin family.
- Post-translational modifications
Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human Calsequestrin 2 protein (ab93736)
15% SDS-PAGE analysis of ab93736 (3μg)
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Product protocols
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